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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH3
All Species:
10.3
Human Site:
S419
Identified Species:
20.61
UniProt:
P20585
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P20585
NP_002430.2
1137
127440
S419
S
E
L
E
T
R
M
S
S
L
Q
P
V
E
L
Chimpanzee
Pan troglodytes
XP_526872
653
74467
Rhesus Macaque
Macaca mulatta
XP_001110439
1124
126700
S407
S
E
L
E
T
R
M
S
N
L
Q
P
V
E
L
Dog
Lupus familis
XP_536307
1124
126796
L408
S
E
L
E
T
R
I
L
C
L
Q
P
V
E
M
Cat
Felis silvestris
Mouse
Mus musculus
P13705
1091
123056
S377
L
E
L
E
T
R
I
S
S
L
Q
P
V
E
L
Rat
Rattus norvegicus
XP_001065837
1105
124697
A377
L
E
L
E
T
R
T
A
S
L
Q
P
V
E
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512218
1058
119728
N368
D
Q
S
E
K
C
I
N
R
I
T
S
I
C
V
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001103184
1083
121769
P378
S
R
I
L
R
I
Q
P
V
E
I
L
V
P
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001193092
988
109454
L317
L
S
E
L
D
T
R
L
H
H
I
Q
P
V
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O65607
1081
119348
M361
N
L
E
D
D
K
E
M
K
L
E
A
A
E
K
Baker's Yeast
Sacchar. cerevisiae
P25336
1018
116515
F346
L
P
L
H
V
A
K
F
F
K
D
I
S
C
P
Red Bread Mold
Neurospora crassa
Q7SD11
1145
125674
S384
E
T
R
L
L
H
I
S
P
C
E
F
L
I
V
Conservation
Percent
Protein Identity:
100
54.1
95.6
83.1
N.A.
78.3
78.8
N.A.
71.5
N.A.
N.A.
50.4
N.A.
N.A.
N.A.
N.A.
40.8
Protein Similarity:
100
56.1
96.6
88.7
N.A.
86
86.2
N.A.
81.2
N.A.
N.A.
68.5
N.A.
N.A.
N.A.
N.A.
57.4
P-Site Identity:
100
0
93.3
73.3
N.A.
86.6
80
N.A.
6.6
N.A.
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
0
100
86.6
N.A.
93.3
86.6
N.A.
46.6
N.A.
N.A.
20
N.A.
N.A.
N.A.
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
36.6
30.4
36.7
Protein Similarity:
N.A.
N.A.
N.A.
55.8
49.5
55.9
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
40
6.6
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
9
0
9
0
0
0
9
9
0
0
% A
% Cys:
0
0
0
0
0
9
0
0
9
9
0
0
0
17
0
% C
% Asp:
9
0
0
9
17
0
0
0
0
0
9
0
0
0
0
% D
% Glu:
9
42
17
50
0
0
9
0
0
9
17
0
0
50
9
% E
% Phe:
0
0
0
0
0
0
0
9
9
0
0
9
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
9
0
9
0
0
9
9
0
0
0
0
0
% H
% Ile:
0
0
9
0
0
9
34
0
0
9
17
9
9
9
0
% I
% Lys:
0
0
0
0
9
9
9
0
9
9
0
0
0
0
9
% K
% Leu:
34
9
50
25
9
0
0
17
0
50
0
9
9
0
34
% L
% Met:
0
0
0
0
0
0
17
9
0
0
0
0
0
0
9
% M
% Asn:
9
0
0
0
0
0
0
9
9
0
0
0
0
0
0
% N
% Pro:
0
9
0
0
0
0
0
9
9
0
0
42
9
9
9
% P
% Gln:
0
9
0
0
0
0
9
0
0
0
42
9
0
0
0
% Q
% Arg:
0
9
9
0
9
42
9
0
9
0
0
0
0
0
0
% R
% Ser:
34
9
9
0
0
0
0
34
25
0
0
9
9
0
9
% S
% Thr:
0
9
0
0
42
9
9
0
0
0
9
0
0
0
0
% T
% Val:
0
0
0
0
9
0
0
0
9
0
0
0
50
9
17
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _