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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PSMC3 All Species: 26.97
Human Site: S186 Identified Species: 39.56
UniProt: P17980 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P17980 NP_002795.2 439 49204 S186 E R P T E Q Y S D I G G L D K
Chimpanzee Pan troglodytes XP_508413 555 61671 S302 E R P T E Q Y S D I G G L D K
Rhesus Macaque Macaca mulatta XP_001106497 439 49185 S186 E R P T E Q Y S D I G G L D K
Dog Lupus familis XP_533187 402 44931 N170 E A I V L P M N H K E K F E N
Cat Felis silvestris
Mouse Mus musculus O88685 442 49474 S189 E R P T E Q Y S D I G G L D K
Rat Rattus norvegicus Q63569 439 49142 S186 E R P T E Q Y S D I G G L D K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q90732 440 49185 A185 K A P Q E T Y A D I G G L D N
Frog Xenopus laevis O42586 404 45258 I167 I Q E L V E A I V L P M N H K
Zebra Danio Brachydanio rerio NP_001002064 404 45291 I167 I Q E L V E A I V L P M N H K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P48601 439 49305 A184 K A P Q E T Y A D I G G L D T
Honey Bee Apis mellifera XP_392722 428 47609 S175 E R P T E Q Y S D I G G L D K
Nematode Worm Caenorhab. elegans O16368 443 49704 A188 K A P Q E T Y A D V G G L D Q
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002330164 423 47370 N170 E K P T E D Y N D I G G L E K
Maize Zea mays NP_001142386 430 47792 N177 E K P T E D Y N D I G G L E K
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O04019 423 47019 N170 E K P T E D Y N D I G G L E K
Baker's Yeast Sacchar. cerevisiae P33297 434 48237 S181 E K P T E T Y S D V G G L D K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 78.9 99.7 91.5 N.A. 97.9 99.3 N.A. N.A. 40 90.8 90.4 N.A. 40 83.8 39.5 N.A.
Protein Similarity: 100 79 100 91.5 N.A. 98.6 99.5 N.A. N.A. 60.9 91.5 91.1 N.A. 60.5 91.1 59.5 N.A.
P-Site Identity: 100 100 100 6.6 N.A. 100 100 N.A. N.A. 60 6.6 6.6 N.A. 60 100 53.3 N.A.
P-Site Similarity: 100 100 100 20 N.A. 100 100 N.A. N.A. 73.3 26.6 26.6 N.A. 73.3 100 80 N.A.
Percent
Protein Identity: 74 75.6 N.A. 73.1 67.6 N.A.
Protein Similarity: 87 88.6 N.A. 85.4 84 N.A.
P-Site Identity: 73.3 73.3 N.A. 73.3 80 N.A.
P-Site Similarity: 93.3 93.3 N.A. 93.3 93.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 25 0 0 0 0 13 19 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 19 0 0 82 0 0 0 0 63 0 % D
% Glu: 69 0 13 0 82 13 0 0 0 0 7 0 0 25 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 82 82 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 7 0 0 0 0 13 0 % H
% Ile: 13 0 7 0 0 0 0 13 0 69 0 0 0 0 0 % I
% Lys: 19 25 0 0 0 0 0 0 0 7 0 7 0 0 75 % K
% Leu: 0 0 0 13 7 0 0 0 0 13 0 0 82 0 0 % L
% Met: 0 0 0 0 0 0 7 0 0 0 0 13 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 25 0 0 0 0 13 0 13 % N
% Pro: 0 0 82 0 0 7 0 0 0 0 13 0 0 0 0 % P
% Gln: 0 13 0 19 0 38 0 0 0 0 0 0 0 0 7 % Q
% Arg: 0 38 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 44 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 63 0 25 0 0 0 0 0 0 0 0 7 % T
% Val: 0 0 0 7 13 0 0 0 13 13 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 82 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _