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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TAT All Species: 27.27
Human Site: S118 Identified Species: 46.15
UniProt: P17735 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P17735 NP_000344.1 454 50399 S118 P S I G F L S S R E E I A S Y
Chimpanzee Pan troglodytes XP_511091 454 50273 S118 P S I G F L S S R E E I A S Y
Rhesus Macaque Macaca mulatta XP_001106194 454 50404 S118 P S I G F L S S R E E I A S Y
Dog Lupus familis XP_536796 454 50314 S118 P S I G Y L S S R E E I A S Y
Cat Felis silvestris
Mouse Mus musculus Q8QZR1 454 50547 S118 P S I G Y L S S R E E V A S Y
Rat Rattus norvegicus P04694 454 50617 S118 P S I G Y L S S R E E V A S Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509220 455 50659 S118 P S I G Y L S S R E D I A S Y
Chicken Gallus gallus XP_414240 455 50533 C118 P S V G Y Q S C R E A V A A Y
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q7T3E5 450 50327 F123 Y D R Q L D P F K E I L V T V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_572953 501 55910 A156 S T Q G H E I A R K A V A K Y
Honey Bee Apis mellifera XP_001121079 425 47891 A116 L C S G C S C A L D L C I T A
Nematode Worm Caenorhab. elegans NP_510454 464 51013 A121 P A V G A L A A R E A I V E R
Sea Urchin Strong. purpuratus XP_796747 395 43489 D107 D A P L T S E D V I L T C G C
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P47039 444 50064 L113 S P I Y N T E L K A E N V T V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 97.1 93.1 N.A. 92 91.6 N.A. 88.1 81.9 N.A. 20.2 N.A. 44.3 51.7 41.3 48.9
Protein Similarity: 100 99.7 98.4 96.6 N.A. 96.6 96 N.A. 94.9 91.8 N.A. 41.4 N.A. 63 67.1 60.9 64.5
P-Site Identity: 100 100 100 93.3 N.A. 86.6 86.6 N.A. 86.6 53.3 N.A. 6.6 N.A. 26.6 6.6 40 0
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 80 N.A. 26.6 N.A. 53.3 26.6 66.6 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 23.3 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 39.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 15 0 0 8 0 8 22 0 8 22 0 65 8 8 % A
% Cys: 0 8 0 0 8 0 8 8 0 0 0 8 8 0 8 % C
% Asp: 8 8 0 0 0 8 0 8 0 8 8 0 0 0 0 % D
% Glu: 0 0 0 0 0 8 15 0 0 72 50 0 0 8 0 % E
% Phe: 0 0 0 0 22 0 0 8 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 79 0 0 0 0 0 0 0 0 0 8 0 % G
% His: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 58 0 0 0 8 0 0 8 8 43 8 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 15 8 0 0 0 8 0 % K
% Leu: 8 0 0 8 8 58 0 8 8 0 15 8 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 8 0 0 0 0 0 0 8 0 0 0 % N
% Pro: 65 8 8 0 0 0 8 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 8 8 0 8 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 8 0 0 0 0 0 72 0 0 0 0 0 8 % R
% Ser: 15 58 8 0 0 15 58 50 0 0 0 0 0 50 0 % S
% Thr: 0 8 0 0 8 8 0 0 0 0 0 8 0 22 0 % T
% Val: 0 0 15 0 0 0 0 0 8 0 0 29 22 0 15 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 8 36 0 0 0 0 0 0 0 0 0 65 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _