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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TSHR
All Species:
22.12
Human Site:
Y185
Identified Species:
54.07
UniProt:
P16473
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16473
NP_000360.2
764
86830
Y185
E
T
L
T
L
K
L
Y
N
N
G
F
T
S
V
Chimpanzee
Pan troglodytes
XP_001166958
764
86856
Y185
E
T
L
T
L
K
L
Y
N
N
G
F
T
S
V
Rhesus Macaque
Macaca mulatta
XP_001104839
764
86873
Y185
E
T
L
T
L
K
L
Y
N
N
G
F
T
S
I
Dog
Lupus familis
XP_538486
704
78758
L164
I
L
E
I
C
D
N
L
H
I
T
T
I
P
G
Cat
Felis silvestris
Mouse
Mus musculus
P47750
764
86565
Y185
E
T
L
T
L
K
L
Y
N
N
G
F
T
S
V
Rat
Rattus norvegicus
P21463
764
86457
Y185
E
T
L
T
L
K
L
Y
N
N
G
F
T
S
I
Wallaby
Macropus eugenll
Q6YNB6
694
78462
I157
D
I
Q
D
N
I
N
I
R
T
I
E
R
N
S
Platypus
Ornith. anatinus
XP_001505603
692
77641
G155
A
F
W
G
T
Y
S
G
P
N
L
L
D
V
S
Chicken
Gallus gallus
P79763
693
78680
H156
L
D
V
Q
D
N
I
H
I
R
T
I
E
R
N
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001139235
757
85360
Y183
D
L
L
S
L
R
L
Y
S
N
G
F
T
K
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
97.2
47.6
N.A.
86.9
85.9
46
65.7
46.7
N.A.
58.3
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
98.8
64.4
N.A.
93.5
93.1
62.8
75.9
62.7
N.A.
74.4
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
0
N.A.
100
93.3
0
6.6
0
N.A.
60
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
6.6
N.A.
100
100
13.3
6.6
20
N.A.
86.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
20
10
0
10
10
10
0
0
0
0
0
0
10
0
0
% D
% Glu:
50
0
10
0
0
0
0
0
0
0
0
10
10
0
0
% E
% Phe:
0
10
0
0
0
0
0
0
0
0
0
60
0
0
0
% F
% Gly:
0
0
0
10
0
0
0
10
0
0
60
0
0
0
10
% G
% His:
0
0
0
0
0
0
0
10
10
0
0
0
0
0
0
% H
% Ile:
10
10
0
10
0
10
10
10
10
10
10
10
10
0
20
% I
% Lys:
0
0
0
0
0
50
0
0
0
0
0
0
0
10
0
% K
% Leu:
10
20
60
0
60
0
60
10
0
0
10
10
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
10
10
20
0
50
70
0
0
0
10
10
% N
% Pro:
0
0
0
0
0
0
0
0
10
0
0
0
0
10
0
% P
% Gln:
0
0
10
10
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
10
0
0
10
10
0
0
10
10
0
% R
% Ser:
0
0
0
10
0
0
10
0
10
0
0
0
0
50
20
% S
% Thr:
0
50
0
50
10
0
0
0
0
10
20
10
60
0
0
% T
% Val:
0
0
10
0
0
0
0
0
0
0
0
0
0
10
40
% V
% Trp:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
10
0
60
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _