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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TSHR All Species: 22.12
Human Site: T111 Identified Species: 54.07
UniProt: P16473 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P16473 NP_000360.2 764 86830 T111 T H I E I R N T R N L T Y I D
Chimpanzee Pan troglodytes XP_001166958 764 86856 T111 T H I E I R N T R N L T Y I D
Rhesus Macaque Macaca mulatta XP_001104839 764 86873 T111 T H I E I R N T R S L T Y I D
Dog Lupus familis XP_538486 704 78758 I94 Q S D S L E K I E A N A F D N
Cat Felis silvestris
Mouse Mus musculus P47750 764 86565 T111 T H I E I R N T R S L T Y I D
Rat Rattus norvegicus P21463 764 86457 T111 T H I E I R N T R S L T Y I D
Wallaby Macropus eugenll Q6YNB6 694 78462 A88 D A L E V I E A D V F S N L P
Platypus Ornith. anatinus XP_001505603 692 77641 I86 D V N F L L E I A D N P F M T
Chicken Gallus gallus P79763 693 78680 E87 N D A L E I I E G N V F S S L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001139235 757 85360 T109 T H I E I R N T R K L T F I H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 97.2 47.6 N.A. 86.9 85.9 46 65.7 46.7 N.A. 58.3 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.7 98.8 64.4 N.A. 93.5 93.1 62.8 75.9 62.7 N.A. 74.4 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 93.3 0 N.A. 93.3 93.3 6.6 0 6.6 N.A. 80 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 20 N.A. 100 100 33.3 26.6 13.3 N.A. 86.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 10 0 0 0 0 10 10 10 0 10 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 20 10 10 0 0 0 0 0 10 10 0 0 0 10 50 % D
% Glu: 0 0 0 70 10 10 20 10 10 0 0 0 0 0 0 % E
% Phe: 0 0 0 10 0 0 0 0 0 0 10 10 30 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % G
% His: 0 60 0 0 0 0 0 0 0 0 0 0 0 0 10 % H
% Ile: 0 0 60 0 60 20 10 20 0 0 0 0 0 60 0 % I
% Lys: 0 0 0 0 0 0 10 0 0 10 0 0 0 0 0 % K
% Leu: 0 0 10 10 20 10 0 0 0 0 60 0 0 10 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % M
% Asn: 10 0 10 0 0 0 60 0 0 30 20 0 10 0 10 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 10 % P
% Gln: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 60 0 0 60 0 0 0 0 0 0 % R
% Ser: 0 10 0 10 0 0 0 0 0 30 0 10 10 10 0 % S
% Thr: 60 0 0 0 0 0 0 60 0 0 0 60 0 0 10 % T
% Val: 0 10 0 0 10 0 0 0 0 10 10 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 50 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _