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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKFB1
All Species:
45.15
Human Site:
Y358
Identified Species:
90.3
UniProt:
P16118
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16118
NP_002616.2
471
54681
Y358
A
L
R
D
Q
D
K
Y
R
Y
R
Y
P
K
G
Chimpanzee
Pan troglodytes
XP_001158340
470
54094
Y357
A
L
R
D
Q
D
K
Y
R
Y
R
Y
P
K
G
Rhesus Macaque
Macaca mulatta
XP_001091907
471
54591
Y358
A
L
R
D
Q
D
K
Y
R
Y
R
Y
P
K
G
Dog
Lupus familis
XP_549023
589
67657
Y476
A
L
R
D
Q
D
K
Y
R
Y
R
Y
P
K
G
Cat
Felis silvestris
Mouse
Mus musculus
P70266
471
54831
Y358
A
L
R
D
Q
D
K
Y
R
Y
R
Y
P
K
G
Rat
Rattus norvegicus
P07953
471
54745
Y358
A
L
R
D
Q
D
K
Y
R
Y
R
Y
P
K
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509392
470
54778
Y357
A
L
R
D
Q
D
K
Y
R
Y
R
Y
P
K
G
Chicken
Gallus gallus
Q91348
470
54386
Y357
A
L
R
D
Q
D
K
Y
R
Y
R
Y
P
K
G
Frog
Xenopus laevis
NP_001088535
470
54750
Y357
A
L
R
D
Q
D
K
Y
R
Y
R
Y
P
K
G
Zebra Danio
Brachydanio rerio
XP_683102
465
54169
Y352
A
L
R
D
Q
D
K
Y
R
Y
R
Y
P
K
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21122
457
52072
Y354
D
D
R
A
T
D
K
Y
H
Y
R
Y
P
S
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32604
452
52576
Y342
R
Y
R
G
G
E
S
Y
R
D
V
V
I
R
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
74.5
98.5
78.7
N.A.
95.5
95.3
N.A.
90.8
79.8
82.1
78.3
N.A.
N.A.
N.A.
49.2
N.A.
Protein Similarity:
100
85.3
99.3
79.4
N.A.
97.4
97.2
N.A.
95.7
88.7
90.8
89.3
N.A.
N.A.
N.A.
67
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
N.A.
N.A.
60
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
N.A.
N.A.
60
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
44.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
64.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
84
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
9
0
84
0
92
0
0
0
9
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
9
9
0
0
0
0
0
0
0
0
0
92
% G
% His:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% I
% Lys:
0
0
0
0
0
0
92
0
0
0
0
0
0
84
0
% K
% Leu:
0
84
0
0
0
0
0
0
0
0
0
0
0
0
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
92
0
0
% P
% Gln:
0
0
0
0
84
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
9
0
100
0
0
0
0
0
92
0
92
0
0
9
0
% R
% Ser:
0
0
0
0
0
0
9
0
0
0
0
0
0
9
0
% S
% Thr:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
9
9
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
9
0
0
0
0
0
100
0
92
0
92
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _