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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TCF4
All Species:
10.91
Human Site:
S528
Identified Species:
30
UniProt:
P15884
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P15884
NP_001077431.1
667
71308
S528
E
N
L
Q
D
T
K
S
S
E
D
K
K
L
D
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001084466
821
88777
S678
E
N
L
Q
D
T
K
S
S
E
D
K
K
L
D
Dog
Lupus familis
XP_542197
632
64907
E519
E
D
D
L
L
P
P
E
Q
K
A
E
R
E
K
Cat
Felis silvestris
Mouse
Mus musculus
Q60722
670
71606
S527
E
N
L
Q
D
T
K
S
S
E
D
K
K
L
D
Rat
Rattus norvegicus
Q62655
589
63035
A490
R
E
K
E
R
R
M
A
N
N
A
R
E
R
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510048
656
70059
R531
K
D
I
K
S
I
T
R
S
R
S
S
N
N
D
Chicken
Gallus gallus
P30985
657
70524
S515
P
S
S
D
D
M
K
S
D
D
E
S
S
Q
K
Frog
Xenopus laevis
Q01978
658
70072
P546
E
D
D
D
N
L
P
P
E
Q
K
A
E
R
E
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P11420
710
73846
A543
S
A
D
E
D
D
D
A
E
P
A
V
K
A
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
80.8
52
N.A.
97.6
85.4
N.A.
94.3
59.6
54.4
N.A.
N.A.
23.1
N.A.
N.A.
N.A.
Protein Similarity:
100
N.A.
81.1
64.3
N.A.
98.3
86
N.A.
95.9
73.1
69.8
N.A.
N.A.
37.6
N.A.
N.A.
N.A.
P-Site Identity:
100
N.A.
100
6.6
N.A.
100
0
N.A.
13.3
20
6.6
N.A.
N.A.
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
N.A.
100
33.3
N.A.
100
33.3
N.A.
40
40
40
N.A.
N.A.
26.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
12
0
0
0
0
0
23
0
0
34
12
0
12
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
34
34
23
56
12
12
0
12
12
34
0
0
0
45
% D
% Glu:
56
12
0
23
0
0
0
12
23
34
12
12
23
12
12
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
12
0
0
12
0
0
0
0
0
0
0
0
12
% I
% Lys:
12
0
12
12
0
0
45
0
0
12
12
34
45
0
23
% K
% Leu:
0
0
34
12
12
12
0
0
0
0
0
0
0
34
12
% L
% Met:
0
0
0
0
0
12
12
0
0
0
0
0
0
0
0
% M
% Asn:
0
34
0
0
12
0
0
0
12
12
0
0
12
12
0
% N
% Pro:
12
0
0
0
0
12
23
12
0
12
0
0
0
0
0
% P
% Gln:
0
0
0
34
0
0
0
0
12
12
0
0
0
12
0
% Q
% Arg:
12
0
0
0
12
12
0
12
0
12
0
12
12
23
0
% R
% Ser:
12
12
12
0
12
0
0
45
45
0
12
23
12
0
0
% S
% Thr:
0
0
0
0
0
34
12
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _