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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TCF4 All Species: 13.03
Human Site: S317 Identified Species: 35.83
UniProt: P15884 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P15884 NP_001077431.1 667 71308 S317 R G S G A A G S S Q T G D A L
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001084466 821 88777 S467 R G S G A A G S S Q T G D A L
Dog Lupus familis XP_542197 632 64907 L316 P V S G A D G L M G S R G T T
Cat Felis silvestris
Mouse Mus musculus Q60722 670 71606 S316 R G T G A A G S S Q T G D A L
Rat Rattus norvegicus Q62655 589 63035 S289 R N G G Q A S S S P N Y E G P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510048 656 70059 Y317 G K A L A S I Y S P D H T N N
Chicken Gallus gallus P30985 657 70524 S314 N P S T P V G S P S P L T G A
Frog Xenopus laevis Q01978 658 70072 L320 T G S S G D A L G K A L A S I
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P11420 710 73846 G320 L T Q S V V G G G G E P S V S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 80.8 52 N.A. 97.6 85.4 N.A. 94.3 59.6 54.4 N.A. N.A. 23.1 N.A. N.A. N.A.
Protein Similarity: 100 N.A. 81.1 64.3 N.A. 98.3 86 N.A. 95.9 73.1 69.8 N.A. N.A. 37.6 N.A. N.A. N.A.
P-Site Identity: 100 N.A. 100 26.6 N.A. 93.3 33.3 N.A. 13.3 20 13.3 N.A. N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 N.A. 100 33.3 N.A. 100 40 N.A. 26.6 20 33.3 N.A. N.A. 6.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 12 0 56 45 12 0 0 0 12 0 12 34 12 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 23 0 0 0 0 12 0 34 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 12 0 12 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 12 45 12 56 12 0 67 12 23 23 0 34 12 23 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 12 0 0 0 % H
% Ile: 0 0 0 0 0 0 12 0 0 0 0 0 0 0 12 % I
% Lys: 0 12 0 0 0 0 0 0 0 12 0 0 0 0 0 % K
% Leu: 12 0 0 12 0 0 0 23 0 0 0 23 0 0 34 % L
% Met: 0 0 0 0 0 0 0 0 12 0 0 0 0 0 0 % M
% Asn: 12 12 0 0 0 0 0 0 0 0 12 0 0 12 12 % N
% Pro: 12 12 0 0 12 0 0 0 12 23 12 12 0 0 12 % P
% Gln: 0 0 12 0 12 0 0 0 0 34 0 0 0 0 0 % Q
% Arg: 45 0 0 0 0 0 0 0 0 0 0 12 0 0 0 % R
% Ser: 0 0 56 23 0 12 12 56 56 12 12 0 12 12 12 % S
% Thr: 12 12 12 12 0 0 0 0 0 0 34 0 23 12 12 % T
% Val: 0 12 0 0 12 23 0 0 0 0 0 0 0 12 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 12 0 0 0 12 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _