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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NME1
All Species:
42.12
Human Site:
S144
Identified Species:
71.28
UniProt:
P15531
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P15531
NP_000260.1
152
17149
S144
E
E
L
V
D
Y
T
S
C
A
Q
N
W
I
Y
Chimpanzee
Pan troglodytes
XP_001147407
308
33377
S300
E
E
L
V
D
Y
K
S
C
A
H
D
W
V
Y
Rhesus Macaque
Macaca mulatta
XP_001096144
240
26905
S232
E
E
L
V
D
Y
M
S
C
A
Q
N
W
I
Y
Dog
Lupus familis
XP_533973
152
17223
S144
E
E
L
V
D
Y
K
S
C
A
Q
N
W
I
Y
Cat
Felis silvestris
Mouse
Mus musculus
P15532
152
17189
S144
E
E
L
V
E
Y
K
S
C
A
Q
N
W
I
Y
Rat
Rattus norvegicus
Q05982
152
17174
S144
E
E
L
V
D
Y
K
S
C
A
Q
N
W
I
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515701
267
30034
S259
E
E
L
T
D
Y
K
S
C
A
H
D
W
I
Y
Chicken
Gallus gallus
O57535
153
17269
S145
A
E
L
I
D
Y
R
S
C
A
H
D
W
V
Y
Frog
Xenopus laevis
P70011
154
17484
S145
E
E
L
V
E
Y
K
S
C
A
Y
E
W
V
Y
Zebra Danio
Brachydanio rerio
NP_571001
153
17215
S145
E
E
L
V
S
F
K
S
C
A
Q
Q
W
I
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P08879
153
17151
P145
K
E
L
V
T
W
T
P
A
A
K
D
W
I
Y
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8LAH8
237
25755
S227
E
E
L
V
S
Y
T
S
N
A
E
K
W
I
Y
Baker's Yeast
Sacchar. cerevisiae
P36010
153
17148
S145
E
E
L
V
D
W
E
S
N
Q
A
K
W
I
Y
Red Bread Mold
Neurospora crassa
Q9UUY8
152
16882
H144
E
E
L
N
Q
W
N
H
H
S
A
A
W
I
F
Conservation
Percent
Protein Identity:
100
41.2
62
88.8
N.A.
94
95.3
N.A.
52
87.5
81.8
84.3
N.A.
77.1
N.A.
N.A.
N.A.
Protein Similarity:
100
45.1
62.5
92.7
N.A.
96
97.3
N.A.
53.9
94.1
91.5
90.8
N.A.
86.9
N.A.
N.A.
N.A.
P-Site Identity:
100
73.3
93.3
93.3
N.A.
86.6
93.3
N.A.
73.3
60
66.6
73.3
N.A.
53.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
86.6
93.3
93.3
N.A.
93.3
93.3
N.A.
80
80
80
80
N.A.
80
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
40.9
58.8
62.5
Protein Similarity:
N.A.
N.A.
N.A.
50.6
76.4
77.6
P-Site Identity:
N.A.
N.A.
N.A.
73.3
60
33.3
P-Site Similarity:
N.A.
N.A.
N.A.
80
66.6
53.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
0
8
86
15
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
72
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
58
0
0
0
0
0
0
29
0
0
0
% D
% Glu:
86
100
0
0
15
0
8
0
0
0
8
8
0
0
0
% E
% Phe:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
8
8
0
22
0
0
0
0
% H
% Ile:
0
0
0
8
0
0
0
0
0
0
0
0
0
79
0
% I
% Lys:
8
0
0
0
0
0
50
0
0
0
8
15
0
0
0
% K
% Leu:
0
0
100
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
8
0
15
0
0
36
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
8
0
0
0
0
8
43
8
0
0
0
% Q
% Arg:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
15
0
0
86
0
8
0
0
0
0
0
% S
% Thr:
0
0
0
8
8
0
22
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
79
0
0
0
0
0
0
0
0
0
22
0
% V
% Trp:
0
0
0
0
0
22
0
0
0
0
0
0
100
0
0
% W
% Tyr:
0
0
0
0
0
72
0
0
0
0
8
0
0
0
93
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _