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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AREG All Species: 10.91
Human Site: S55 Identified Species: 30
UniProt: P15514 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P15514 NP_001648.1 252 27895 S55 G F E V T S R S E M S S G S E
Chimpanzee Pan troglodytes XP_517224 252 27951 S55 G F E V T S R S E M S S G S E
Rhesus Macaque Macaca mulatta XP_001101978 252 28005 S55 G F E V T S R S E M S S G S E
Dog Lupus familis XP_532410 396 43657 G198 G L Q V T P R G G M S S G S E
Cat Felis silvestris
Mouse Mus musculus P31955 248 27531 R55 G L E L S V G R E V S T I S E
Rat Rattus norvegicus P24338 243 26615 S55 G L V V S E V S T I S E M P S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511015 221 24746 E53 T D E D Y N S E E Y E N E P Q
Chicken Gallus gallus NP_001026708 210 23647 E50 G S D Y E E E E Y E E A P L A
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001104696 230 25617 E62 V E Y E E E D E E Y Y Y D D D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98 96.4 52.7 N.A. 70.2 70.2 N.A. 50.7 42 N.A. 24.2 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.2 98.4 57.5 N.A. 81.3 80.1 N.A. 65 55.5 N.A. 44 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 66.6 N.A. 40 26.6 N.A. 13.3 6.6 N.A. 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 73.3 N.A. 66.6 40 N.A. 33.3 20 N.A. 13.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 12 0 0 12 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 12 12 12 0 0 12 0 0 0 0 0 12 12 12 % D
% Glu: 0 12 56 12 23 34 12 34 67 12 23 12 12 0 56 % E
% Phe: 0 34 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 78 0 0 0 0 0 12 12 12 0 0 0 45 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 12 0 0 12 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 34 0 12 0 0 0 0 0 0 0 0 0 12 0 % L
% Met: 0 0 0 0 0 0 0 0 0 45 0 0 12 0 0 % M
% Asn: 0 0 0 0 0 12 0 0 0 0 0 12 0 0 0 % N
% Pro: 0 0 0 0 0 12 0 0 0 0 0 0 12 23 0 % P
% Gln: 0 0 12 0 0 0 0 0 0 0 0 0 0 0 12 % Q
% Arg: 0 0 0 0 0 0 45 12 0 0 0 0 0 0 0 % R
% Ser: 0 12 0 0 23 34 12 45 0 0 67 45 0 56 12 % S
% Thr: 12 0 0 0 45 0 0 0 12 0 0 12 0 0 0 % T
% Val: 12 0 12 56 0 12 12 0 0 12 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 12 12 12 0 0 0 12 23 12 12 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _