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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EZR All Species: 20
Human Site: Y499 Identified Species: 48.89
UniProt: P15311 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P15311 NP_001104547.1 586 69413 Y499 E G A E P T G Y S A E L S S E
Chimpanzee Pan troglodytes XP_522176 765 86955 A678 H D E N N A E A S A E L S N E
Rhesus Macaque Macaca mulatta XP_001093089 756 88442 Y669 E G A E P T G Y S A E L S S E
Dog Lupus familis XP_541173 586 69404 Y499 E G T E Y T G Y S A E L S S E
Cat Felis silvestris
Mouse Mus musculus P26040 586 69388 Y499 E G A E P M G Y S A E L S S E
Rat Rattus norvegicus P31977 586 69372 Y499 E G A E P M G Y S A E L S S E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q9PU45 583 68536 A496 H D E N N A E A S A E L S S D
Frog Xenopus laevis NP_001087392 582 69042 Y495 D G L D H T S Y S A D L P S V
Zebra Danio Brachydanio rerio O57457 619 70690 R534 S R H R S R S R S P D V Q A K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P46150 578 68123 D491 T N G D A G G D V S R D L D T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 58.4 76.8 97.2 N.A. 96.5 96.4 N.A. N.A. 76.4 81.7 22.2 N.A. 57.8 N.A. N.A. N.A.
Protein Similarity: 100 68.5 77.3 98.9 N.A. 99.1 99.1 N.A. N.A. 89.2 92.3 41.5 N.A. 75 N.A. N.A. N.A.
P-Site Identity: 100 40 100 86.6 N.A. 93.3 93.3 N.A. N.A. 40 46.6 6.6 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 46.6 100 86.6 N.A. 93.3 93.3 N.A. N.A. 46.6 66.6 33.3 N.A. 20 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 40 0 10 20 0 20 0 80 0 0 0 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 20 0 20 0 0 0 10 0 0 20 10 0 10 10 % D
% Glu: 50 0 20 50 0 0 20 0 0 0 70 0 0 0 60 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 60 10 0 0 10 60 0 0 0 0 0 0 0 0 % G
% His: 20 0 10 0 10 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % K
% Leu: 0 0 10 0 0 0 0 0 0 0 0 80 10 0 0 % L
% Met: 0 0 0 0 0 20 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 10 0 20 20 0 0 0 0 0 0 0 0 10 0 % N
% Pro: 0 0 0 0 40 0 0 0 0 10 0 0 10 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % Q
% Arg: 0 10 0 10 0 10 0 10 0 0 10 0 0 0 0 % R
% Ser: 10 0 0 0 10 0 20 0 90 10 0 0 70 70 0 % S
% Thr: 10 0 10 0 0 40 0 0 0 0 0 0 0 0 10 % T
% Val: 0 0 0 0 0 0 0 0 10 0 0 10 0 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 10 0 0 60 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _