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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EZR All Species: 19.09
Human Site: Y354 Identified Species: 46.67
UniProt: P15311 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P15311 NP_001104547.1 586 69413 Y354 L M L R L Q D Y E E K T K K A
Chimpanzee Pan troglodytes XP_522176 765 86955 I536 L M E R L K Q I E E Q T I K A
Rhesus Macaque Macaca mulatta XP_001093089 756 88442 Y524 L M L R L Q D Y E E K T K K A
Dog Lupus familis XP_541173 586 69404 Y354 L M L R L Q D Y E E K T K K A
Cat Felis silvestris
Mouse Mus musculus P26040 586 69388 Y354 L M L R L Q D Y E Q K T K R A
Rat Rattus norvegicus P31977 586 69372 F354 L M L R L Q D F E Q K T K R A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q9PU45 583 68536 I354 L M E R L R Q I E E Q T M K A
Frog Xenopus laevis NP_001087392 582 69042 Y354 L M F R L H E Y E E Q S K R A
Zebra Danio Brachydanio rerio O57457 619 70690 Y419 D A P Q S G L Y N S A S E R N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P46150 578 68123 D351 R L K Q M Q E D M E R S Q R D
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 58.4 76.8 97.2 N.A. 96.5 96.4 N.A. N.A. 76.4 81.7 22.2 N.A. 57.8 N.A. N.A. N.A.
Protein Similarity: 100 68.5 77.3 98.9 N.A. 99.1 99.1 N.A. N.A. 89.2 92.3 41.5 N.A. 75 N.A. N.A. N.A.
P-Site Identity: 100 60 100 100 N.A. 86.6 80 N.A. N.A. 60 60 6.6 N.A. 13.3 N.A. N.A. N.A.
P-Site Similarity: 100 73.3 100 100 N.A. 100 100 N.A. N.A. 73.3 86.6 33.3 N.A. 66.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 0 0 0 0 0 0 0 10 0 0 0 80 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 0 0 0 0 0 50 10 0 0 0 0 0 0 10 % D
% Glu: 0 0 20 0 0 0 20 0 80 70 0 0 10 0 0 % E
% Phe: 0 0 10 0 0 0 0 10 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 20 0 0 0 0 10 0 0 % I
% Lys: 0 0 10 0 0 10 0 0 0 0 50 0 60 50 0 % K
% Leu: 80 10 50 0 80 0 10 0 0 0 0 0 0 0 0 % L
% Met: 0 80 0 0 10 0 0 0 10 0 0 0 10 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 10 % N
% Pro: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 20 0 60 20 0 0 20 30 0 10 0 0 % Q
% Arg: 10 0 0 80 0 10 0 0 0 0 10 0 0 50 0 % R
% Ser: 0 0 0 0 10 0 0 0 0 10 0 30 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 70 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 60 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _