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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EZR All Species: 21.21
Human Site: S413 Identified Species: 51.85
UniProt: P15311 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P15311 NP_001104547.1 586 69413 S413 Q A V D Q I K S Q E Q L A A E
Chimpanzee Pan troglodytes XP_522176 765 86955 N595 Q A A D Q M K N Q E Q L A A E
Rhesus Macaque Macaca mulatta XP_001093089 756 88442 S583 Q A V D Q I K S Q E Q L A A E
Dog Lupus familis XP_541173 586 69404 S413 Q A A D Q I K S Q E Q L A A E
Cat Felis silvestris
Mouse Mus musculus P26040 586 69388 S413 Q A Q D Q I K S Q E Q L A A E
Rat Rattus norvegicus P31977 586 69372 S413 Q A Q D Q I K S Q E Q L A A E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q9PU45 583 68536 N413 Q A A D Q M K N Q E Q L A A E
Frog Xenopus laevis NP_001087392 582 69042 S413 Q S I A Q T E S Q E Q L A S E
Zebra Danio Brachydanio rerio O57457 619 70690 H449 G S E N E P R H R R G Q T A D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P46150 578 68123 L411 E A V E K L K L E E E I M A K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 58.4 76.8 97.2 N.A. 96.5 96.4 N.A. N.A. 76.4 81.7 22.2 N.A. 57.8 N.A. N.A. N.A.
Protein Similarity: 100 68.5 77.3 98.9 N.A. 99.1 99.1 N.A. N.A. 89.2 92.3 41.5 N.A. 75 N.A. N.A. N.A.
P-Site Identity: 100 80 100 93.3 N.A. 93.3 93.3 N.A. N.A. 80 60 6.6 N.A. 33.3 N.A. N.A. N.A.
P-Site Similarity: 100 93.3 100 93.3 N.A. 93.3 93.3 N.A. N.A. 93.3 86.6 46.6 N.A. 86.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 80 30 10 0 0 0 0 0 0 0 0 80 90 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 70 0 0 0 0 0 0 0 0 0 0 10 % D
% Glu: 10 0 10 10 10 0 10 0 10 90 10 0 0 0 80 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 10 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % H
% Ile: 0 0 10 0 0 50 0 0 0 0 0 10 0 0 0 % I
% Lys: 0 0 0 0 10 0 80 0 0 0 0 0 0 0 10 % K
% Leu: 0 0 0 0 0 10 0 10 0 0 0 80 0 0 0 % L
% Met: 0 0 0 0 0 20 0 0 0 0 0 0 10 0 0 % M
% Asn: 0 0 0 10 0 0 0 20 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % P
% Gln: 80 0 20 0 80 0 0 0 80 0 80 10 0 0 0 % Q
% Arg: 0 0 0 0 0 0 10 0 10 10 0 0 0 0 0 % R
% Ser: 0 20 0 0 0 0 0 60 0 0 0 0 0 10 0 % S
% Thr: 0 0 0 0 0 10 0 0 0 0 0 0 10 0 0 % T
% Val: 0 0 30 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _