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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AKR1B1
All Species:
32.73
Human Site:
Y40
Identified Species:
80
UniProt:
P15121
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P15121
NP_001619.1
316
35853
Y40
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
Chimpanzee
Pan troglodytes
XP_001138232
388
43158
Y112
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
Rhesus Macaque
Macaca mulatta
XP_001100679
316
35748
Y40
K
V
A
I
D
V
G
Y
R
H
I
D
C
A
H
Dog
Lupus familis
XP_539451
316
35679
Y40
K
V
A
I
D
L
G
Y
R
H
I
D
C
A
H
Cat
Felis silvestris
Mouse
Mus musculus
P45376
316
35714
Y40
K
V
A
I
D
L
G
Y
R
H
I
D
C
A
Q
Rat
Rattus norvegicus
P07943
316
35779
Y40
K
V
A
I
D
M
G
Y
R
H
I
D
C
A
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512123
306
34973
H40
F
D
C
A
Y
I
Y
H
N
E
D
E
V
G
N
Chicken
Gallus gallus
Q5ZK84
327
37058
Y43
K
Y
A
L
S
V
G
Y
R
H
V
D
C
A
A
Frog
Xenopus laevis
Q6GMC7
327
37081
Y43
K
Y
A
L
G
V
G
Y
R
H
I
D
C
A
F
Zebra Danio
Brachydanio rerio
Q6AZW2
324
36744
Y40
L
A
A
L
D
C
G
Y
R
H
I
D
C
A
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
79.1
98
89.8
N.A.
85.4
85.4
N.A.
72.1
52.2
53.2
51.8
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
79.6
98.7
96.1
N.A.
92.7
93
N.A.
82.9
70
70.9
68.8
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
86.6
86.6
N.A.
0
66.6
73.3
66.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
26.6
80
80
73.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
90
10
0
0
0
0
0
0
0
0
0
90
20
% A
% Cys:
0
0
10
0
0
10
0
0
0
0
0
0
90
0
0
% C
% Asp:
0
10
0
0
70
0
0
0
0
0
10
90
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
10
0
10
0
0
0
% E
% Phe:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% F
% Gly:
0
0
0
0
10
0
90
0
0
0
0
0
0
10
0
% G
% His:
0
0
0
0
0
0
0
10
0
90
0
0
0
0
40
% H
% Ile:
0
0
0
60
0
10
0
0
0
0
80
0
0
0
0
% I
% Lys:
80
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
10
0
0
30
0
20
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
10
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
20
% Q
% Arg:
0
0
0
0
0
0
0
0
90
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
60
0
0
0
50
0
0
0
0
10
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
20
0
0
10
0
10
90
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _