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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IDE
All Species:
21.52
Human Site:
T451
Identified Species:
39.44
UniProt:
P14735
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P14735
NP_004960.2
1019
117968
T451
Y
P
L
E
E
V
L
T
A
E
Y
L
L
E
E
Chimpanzee
Pan troglodytes
XP_507922
1019
117940
T451
Y
P
L
E
E
V
L
T
A
E
Y
L
L
E
E
Rhesus Macaque
Macaca mulatta
XP_001090249
1019
118039
T451
Y
P
L
E
E
V
L
T
A
E
Y
L
L
E
E
Dog
Lupus familis
XP_534963
994
115049
T451
Y
P
L
E
E
V
L
T
A
E
Y
L
L
E
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHR7
1019
117754
T451
Y
P
L
N
G
V
L
T
A
E
Y
L
L
E
E
Rat
Rattus norvegicus
P35559
1019
117692
T451
Y
P
L
N
G
V
L
T
A
E
Y
L
L
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506502
1301
148202
A733
Y
P
L
E
E
V
L
A
A
E
Y
L
L
E
E
Chicken
Gallus gallus
XP_421686
948
108257
P403
R
Q
L
Y
K
V
V
P
I
K
D
I
R
N
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001082994
978
113240
A410
Y
P
L
E
E
I
L
A
A
E
Y
L
L
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P22817
990
113666
I424
F
P
L
E
E
V
L
I
A
P
Y
L
S
N
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10040
856
98243
E349
D
L
S
T
E
G
L
E
H
V
D
D
V
I
Q
Sea Urchin
Strong. purpuratus
XP_001194830
745
84166
A238
E
I
V
L
Q
L
F
A
N
V
E
N
K
N
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q06010
1027
117560
L462
Y
I
P
V
S
R
I
L
A
M
G
L
L
T
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.9
99.4
96.1
N.A.
95
95.4
N.A.
74.4
68.3
N.A.
85.7
N.A.
45.3
N.A.
34.2
46.3
Protein Similarity:
100
99.9
99.7
96.7
N.A.
97.4
97.6
N.A.
76.6
75.4
N.A.
92.1
N.A.
65.1
N.A.
50.9
59.6
P-Site Identity:
100
100
100
100
N.A.
86.6
86.6
N.A.
93.3
13.3
N.A.
86.6
N.A.
66.6
N.A.
13.3
0
P-Site Similarity:
100
100
100
100
N.A.
86.6
86.6
N.A.
93.3
40
N.A.
93.3
N.A.
73.3
N.A.
26.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
36.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
57
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
24
77
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
0
0
0
0
16
8
0
0
0
% D
% Glu:
8
0
0
54
62
0
0
8
0
62
8
0
0
62
70
% E
% Phe:
8
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
16
8
0
0
0
0
8
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
0
16
0
0
0
8
8
8
8
0
0
8
0
8
0
% I
% Lys:
0
0
0
0
8
0
0
0
0
8
0
0
8
0
8
% K
% Leu:
0
8
77
8
0
8
77
8
0
0
0
77
70
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
0
0
0
16
0
0
0
0
8
0
0
8
0
24
0
% N
% Pro:
0
70
8
0
0
0
0
8
0
8
0
0
0
0
0
% P
% Gln:
0
8
0
0
8
0
0
0
0
0
0
0
0
0
8
% Q
% Arg:
8
0
0
0
0
8
0
0
0
0
0
0
8
0
0
% R
% Ser:
0
0
8
0
8
0
0
0
0
0
0
0
8
0
0
% S
% Thr:
0
0
0
8
0
0
0
47
0
0
0
0
0
8
0
% T
% Val:
0
0
8
8
0
70
8
0
0
16
0
0
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
70
0
0
8
0
0
0
0
0
0
70
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _