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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRKCSH All Species: 26.67
Human Site: Y423 Identified Species: 48.89
UniProt: P14314 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P14314 NP_001001329.1 528 59425 Y423 Y E L T T N E Y V Y R L C P F
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_542057 593 66107 Y488 Y E L T T N E Y I Y R L C P F
Cat Felis silvestris
Mouse Mus musculus O08795 521 58774 Y416 Y E L T T N E Y V Y R L C P F
Rat Rattus norvegicus NP_001100276 525 59200 Y420 Y E L T T N E Y V Y R L C P F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510649 692 76488 Y464 Y E L T T N E Y I Y R L C P F
Chicken Gallus gallus
Frog Xenopus laevis NP_001086185 514 57354 T408 G E C Y E L S T S E Y V Y S L
Zebra Danio Brachydanio rerio NP_957347 529 59566 Y424 Y E L S T S E Y I Y R L C P F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609844 548 61521 E443 C Y N F E D R E Y V Y T L C P
Honey Bee Apis mellifera XP_625125 493 56012 N388 G E C F E F R N V E Y I Y T L
Nematode Worm Caenorhab. elegans NP_496073 507 58044 V403 D K C F D R N V Q Q Y T Y Q F
Sea Urchin Strong. purpuratus XP_789169 523 60041 Y417 Y E Y T D R E Y T Y K L C P F
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001146004 602 67827 E488 S F Y D Q C F E T K E G K Y T
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q04924 702 79889 K598 E K Y A E H L K A T Y D E K S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. 80.9 N.A. 86.7 85.2 N.A. 53.6 N.A. 62.3 62.3 N.A. 38.3 41.4 36.7 43.7
Protein Similarity: 100 N.A. N.A. 83.9 N.A. 92.9 91.6 N.A. 61.9 N.A. 77 76.7 N.A. 53.2 57.9 56.4 59.4
P-Site Identity: 100 N.A. N.A. 93.3 N.A. 100 100 N.A. 93.3 N.A. 6.6 80 N.A. 0 13.3 6.6 66.6
P-Site Similarity: 100 N.A. N.A. 100 N.A. 100 100 N.A. 100 N.A. 13.3 100 N.A. 6.6 20 13.3 73.3
Percent
Protein Identity: N.A. 31.8 N.A. N.A. 21.9 N.A.
Protein Similarity: N.A. 48.6 N.A. N.A. 39.8 N.A.
P-Site Identity: N.A. 0 N.A. N.A. 0 N.A.
P-Site Similarity: N.A. 0 N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 0 0 0 8 0 0 0 0 0 0 % A
% Cys: 8 0 24 0 0 8 0 0 0 0 0 0 54 8 0 % C
% Asp: 8 0 0 8 16 8 0 0 0 0 0 8 0 0 0 % D
% Glu: 8 70 0 0 31 0 54 16 0 16 8 0 8 0 0 % E
% Phe: 0 8 0 24 0 8 8 0 0 0 0 0 0 0 62 % F
% Gly: 16 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % G
% His: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 24 0 0 8 0 0 0 % I
% Lys: 0 16 0 0 0 0 0 8 0 8 8 0 8 8 0 % K
% Leu: 0 0 47 0 0 8 8 0 0 0 0 54 8 0 16 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 8 0 0 39 8 8 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 54 8 % P
% Gln: 0 0 0 0 8 0 0 0 8 8 0 0 0 8 0 % Q
% Arg: 0 0 0 0 0 16 16 0 0 0 47 0 0 0 0 % R
% Ser: 8 0 0 8 0 8 8 0 8 0 0 0 0 8 8 % S
% Thr: 0 0 0 47 47 0 0 8 16 8 0 16 0 8 8 % T
% Val: 0 0 0 0 0 0 0 8 31 8 0 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 54 8 24 8 0 0 0 54 8 54 39 0 24 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _