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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRKCSH
All Species:
21.82
Human Site:
S249
Identified Species:
40
UniProt:
P14314
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P14314
NP_001001329.1
528
59425
S249
T
D
G
D
G
A
L
S
E
A
E
A
Q
A
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542057
593
66107
S304
T
D
G
D
G
V
L
S
E
G
E
A
Q
A
L
Cat
Felis silvestris
Mouse
Mus musculus
O08795
521
58774
S249
T
D
G
D
G
A
L
S
E
E
E
A
Q
A
L
Rat
Rattus norvegicus
NP_001100276
525
59200
S248
T
D
G
D
G
G
L
S
E
E
E
A
Q
A
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510649
692
76488
T288
P
D
D
D
G
T
L
T
E
A
E
A
Q
A
L
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001086185
514
57354
D244
L
L
S
H
P
E
L
D
V
D
G
D
G
A
M
Zebra Danio
Brachydanio rerio
NP_957347
529
59566
S254
S
D
T
D
G
T
L
S
E
A
E
A
K
G
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609844
548
61521
T268
R
D
R
N
G
V
V
T
V
E
E
A
K
Y
F
Honey Bee
Apis mellifera
XP_625125
493
56012
P213
K
T
I
E
S
E
Q
P
A
Q
E
E
G
E
E
Nematode Worm
Caenorhab. elegans
NP_496073
507
58044
N231
D
E
L
D
L
D
K
N
G
K
I
D
K
E
E
Sea Urchin
Strong. purpuratus
XP_789169
523
60041
N215
T
D
S
S
G
D
L
N
E
E
E
A
K
A
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001146004
602
67827
N240
D
H
L
Q
E
G
E
N
K
H
D
G
H
A
T
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q04924
702
79889
N431
S
E
V
T
S
F
V
N
E
N
A
P
K
V
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
80.9
N.A.
86.7
85.2
N.A.
53.6
N.A.
62.3
62.3
N.A.
38.3
41.4
36.7
43.7
Protein Similarity:
100
N.A.
N.A.
83.9
N.A.
92.9
91.6
N.A.
61.9
N.A.
77
76.7
N.A.
53.2
57.9
56.4
59.4
P-Site Identity:
100
N.A.
N.A.
86.6
N.A.
93.3
86.6
N.A.
73.3
N.A.
13.3
66.6
N.A.
26.6
6.6
6.6
53.3
P-Site Similarity:
100
N.A.
N.A.
86.6
N.A.
93.3
86.6
N.A.
80
N.A.
20
80
N.A.
53.3
13.3
26.6
73.3
Percent
Protein Identity:
N.A.
31.8
N.A.
N.A.
21.9
N.A.
Protein Similarity:
N.A.
48.6
N.A.
N.A.
39.8
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
16
0
0
8
24
8
62
0
62
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
16
62
8
54
0
16
0
8
0
8
8
16
0
0
0
% D
% Glu:
0
16
0
8
8
16
8
0
62
31
70
8
0
16
16
% E
% Phe:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
0
31
0
62
16
0
0
8
8
8
8
16
8
0
% G
% His:
0
8
0
8
0
0
0
0
0
8
0
0
8
0
0
% H
% Ile:
0
0
8
0
0
0
0
0
0
0
8
0
0
0
0
% I
% Lys:
8
0
0
0
0
0
8
0
8
8
0
0
39
0
0
% K
% Leu:
8
8
16
0
8
0
62
0
0
0
0
0
0
0
54
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
8
0
0
0
31
0
8
0
0
0
0
0
% N
% Pro:
8
0
0
0
8
0
0
8
0
0
0
8
0
0
0
% P
% Gln:
0
0
0
8
0
0
8
0
0
8
0
0
39
0
0
% Q
% Arg:
8
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
16
0
16
8
16
0
0
39
0
0
0
0
0
0
0
% S
% Thr:
39
8
8
8
0
16
0
16
0
0
0
0
0
0
8
% T
% Val:
0
0
8
0
0
16
16
0
16
0
0
0
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _