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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSE
All Species:
4.55
Human Site:
S40
Identified Species:
12.5
UniProt:
P14091
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P14091
NP_001901.1
401
43312
S40
K
K
K
L
R
A
R
S
Q
L
S
E
F
W
K
Chimpanzee
Pan troglodytes
XP_514145
392
42339
S40
K
K
K
L
R
A
R
S
Q
L
S
E
F
W
K
Rhesus Macaque
Macaca mulatta
P11489
388
41678
L38
N
L
S
E
H
G
L
L
K
D
F
L
K
K
H
Dog
Lupus familis
XP_545694
428
46756
K67
R
H
Q
S
L
R
K
K
L
R
A
R
G
Q
L
Cat
Felis silvestris
Mouse
Mus musculus
P70269
397
42914
G41
R
K
K
L
R
A
Q
G
Q
L
S
E
F
W
R
Rat
Rattus norvegicus
P16228
398
43003
G42
R
K
K
L
R
A
Q
G
Q
L
S
D
F
W
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P16476
383
41701
L38
I
L
R
E
K
G
L
L
H
H
F
L
Q
H
H
Frog
Xenopus laevis
Q805F3
397
42889
L38
T
L
K
E
K
G
K
L
S
H
I
W
T
Q
Q
Zebra Danio
Brachydanio rerio
NP_571879
416
46089
H48
L
E
E
F
L
K
Q
H
Q
P
D
M
F
S
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.2
52.8
82.2
N.A.
81.8
82.7
N.A.
N.A.
51.8
67.8
47.5
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
97.2
69.3
86.4
N.A.
88.5
89.5
N.A.
N.A.
67.5
78
66.1
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
0
0
N.A.
73.3
66.6
N.A.
N.A.
0
6.6
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
6.6
26.6
N.A.
93.3
93.3
N.A.
N.A.
13.3
26.6
40
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
45
0
0
0
0
12
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
12
12
12
0
0
0
% D
% Glu:
0
12
12
34
0
0
0
0
0
0
0
34
0
0
0
% E
% Phe:
0
0
0
12
0
0
0
0
0
0
23
0
56
0
0
% F
% Gly:
0
0
0
0
0
34
0
23
0
0
0
0
12
0
0
% G
% His:
0
12
0
0
12
0
0
12
12
23
0
0
0
12
23
% H
% Ile:
12
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% I
% Lys:
23
45
56
0
23
12
23
12
12
0
0
0
12
12
23
% K
% Leu:
12
34
0
45
23
0
23
34
12
45
0
23
0
0
12
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% M
% Asn:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
0
% P
% Gln:
0
0
12
0
0
0
34
0
56
0
0
0
12
23
12
% Q
% Arg:
34
0
12
0
45
12
23
0
0
12
0
12
0
0
34
% R
% Ser:
0
0
12
12
0
0
0
23
12
0
45
0
0
12
0
% S
% Thr:
12
0
0
0
0
0
0
0
0
0
0
0
12
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
12
0
45
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _