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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
XRCC6
All Species:
14.85
Human Site:
S222
Identified Species:
23.33
UniProt:
P12956
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P12956
NP_001460.1
609
69843
S222
L
F
Y
R
D
I
I
S
I
A
E
D
E
D
L
Chimpanzee
Pan troglodytes
XP_521301
565
64749
R197
S
K
L
E
D
L
L
R
K
V
R
A
K
E
T
Rhesus Macaque
Macaca mulatta
XP_001105684
559
64235
R197
E
D
L
L
R
K
V
R
A
K
E
T
R
K
R
Dog
Lupus familis
XP_531714
608
69589
S220
L
F
Y
R
D
I
I
S
I
A
E
D
E
D
L
Cat
Felis silvestris
Mouse
Mus musculus
P23475
608
69466
T220
V
F
Y
R
D
I
I
T
T
A
E
D
E
D
L
Rat
Rattus norvegicus
NP_620780
608
69468
S220
L
F
Y
R
D
I
I
S
I
A
E
D
E
D
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507917
413
47433
K68
R
L
N
L
R
L
G
K
D
V
A
L
T
V
S
Chicken
Gallus gallus
O93257
632
72271
N244
L
F
Y
R
D
I
I
N
V
A
E
D
E
D
L
Frog
Xenopus laevis
NP_001082274
611
69251
N220
L
F
Y
R
D
I
V
N
T
A
E
D
E
D
L
Zebra Danio
Brachydanio rerio
NP_956198
409
46098
R64
D
M
T
M
Q
C
V
R
S
V
Y
T
S
K
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q23976
631
72517
S223
Y
K
E
F
I
T
L
S
R
A
I
E
L
D
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001189673
580
65781
V220
S
E
F
Y
Q
D
I
V
H
G
S
E
D
E
E
Poplar Tree
Populus trichocarpa
XP_002317447
628
70376
G232
L
F
Y
S
D
L
I
G
L
E
G
D
E
L
A
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_564012
621
70272
G233
L
F
Y
K
D
L
I
G
L
N
S
D
E
L
T
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7SA95
645
72334
A233
I
I
Y
R
N
P
A
A
E
A
G
Q
S
E
S
Conservation
Percent
Protein Identity:
100
88
89.8
84.7
N.A.
83.2
83.2
N.A.
53.6
68
65.6
39
N.A.
25
N.A.
N.A.
45.6
Protein Similarity:
100
89.3
91.1
92.9
N.A.
90.9
91.7
N.A.
59.9
81.9
81.1
53.2
N.A.
45.9
N.A.
N.A.
64.8
P-Site Identity:
100
6.6
6.6
100
N.A.
80
100
N.A.
0
86.6
80
0
N.A.
20
N.A.
N.A.
6.6
P-Site Similarity:
100
33.3
13.3
100
N.A.
93.3
100
N.A.
6.6
100
93.3
13.3
N.A.
33.3
N.A.
N.A.
33.3
Percent
Protein Identity:
30.7
N.A.
N.A.
30.2
N.A.
27.6
Protein Similarity:
50
N.A.
N.A.
48.6
N.A.
48.5
P-Site Identity:
46.6
N.A.
N.A.
46.6
N.A.
20
P-Site Similarity:
60
N.A.
N.A.
66.6
N.A.
46.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
7
7
7
54
7
7
0
0
14
% A
% Cys:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
7
0
0
60
7
0
0
7
0
0
54
7
47
0
% D
% Glu:
7
7
7
7
0
0
0
0
7
7
47
14
54
20
7
% E
% Phe:
0
54
7
7
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
7
14
0
7
14
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% H
% Ile:
7
7
0
0
7
40
54
0
20
0
7
0
0
0
7
% I
% Lys:
0
14
0
7
0
7
0
7
7
7
0
0
7
14
0
% K
% Leu:
47
7
14
14
0
27
14
0
14
0
0
7
7
14
40
% L
% Met:
0
7
0
7
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
7
0
7
0
0
14
0
7
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
14
0
0
0
0
0
0
7
0
0
0
% Q
% Arg:
7
0
0
47
14
0
0
20
7
0
7
0
7
0
7
% R
% Ser:
14
0
0
7
0
0
0
27
7
0
14
0
14
0
14
% S
% Thr:
0
0
7
0
0
7
0
7
14
0
0
14
7
0
14
% T
% Val:
7
0
0
0
0
0
20
7
7
20
0
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
60
7
0
0
0
0
0
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _