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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DBT
All Species:
27.88
Human Site:
T171
Identified Species:
47.18
UniProt:
P11182
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11182
NP_001909.2
482
53487
T171
Q
E
I
K
G
R
K
T
L
A
T
P
A
V
R
Chimpanzee
Pan troglodytes
NP_001136231
524
58122
T171
Q
E
I
K
G
R
K
T
L
A
T
P
A
V
R
Rhesus Macaque
Macaca mulatta
XP_001107312
482
53448
T171
Q
E
I
K
G
R
K
T
L
A
T
P
A
V
R
Dog
Lupus familis
XP_537055
482
53272
T171
Q
E
I
K
G
Q
K
T
L
A
T
P
A
V
R
Cat
Felis silvestris
Mouse
Mus musculus
P53395
482
53142
T171
Q
E
I
K
G
Q
K
T
L
A
T
P
A
V
R
Rat
Rattus norvegicus
NP_445764
482
53255
T171
Q
E
I
K
G
Q
K
T
L
A
T
P
A
V
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515929
309
33592
G14
I
K
L
S
E
V
I
G
T
G
K
D
G
R
I
Chicken
Gallus gallus
NP_989987
493
53980
H171
T
H
Q
E
I
K
G
H
K
T
L
A
T
P
A
Frog
Xenopus laevis
NP_001087792
492
53684
H170
T
H
Q
E
I
K
G
H
K
T
L
A
T
P
A
Zebra Danio
Brachydanio rerio
NP_001013533
493
53907
T172
Q
E
I
K
G
H
K
T
Q
A
T
P
A
V
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_573000
462
50055
R167
I
P
A
T
P
S
V
R
R
L
A
K
E
H
Q
Honey Bee
Apis mellifera
XP_624936
501
57231
S177
D
I
V
L
I
G
N
S
L
L
D
I
E
L
D
Nematode Worm
Caenorhab. elegans
NP_495670
448
49673
R153
L
A
T
P
A
V
R
R
I
A
I
E
N
K
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q5M729
539
58449
P218
K
A
E
P
T
P
A
P
P
K
E
E
K
V
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91.7
98.1
91.4
N.A.
87.7
87.7
N.A.
52.7
75.4
73.5
69.7
N.A.
49.1
47.9
50.8
N.A.
Protein Similarity:
100
91.9
99.1
96.2
N.A.
93.3
93.9
N.A.
59.3
86
85.5
80.1
N.A.
66.1
63.6
66.1
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
0
0
0
86.6
N.A.
0
6.6
6.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
13.3
13.3
13.3
86.6
N.A.
6.6
26.6
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
25.6
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
42.8
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
15
8
0
8
0
8
0
0
58
8
15
50
0
15
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
0
0
0
0
8
8
0
0
8
% D
% Glu:
0
50
8
15
8
0
0
0
0
0
8
15
15
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
50
8
15
8
0
8
0
0
8
0
0
% G
% His:
0
15
0
0
0
8
0
15
0
0
0
0
0
8
0
% H
% Ile:
15
8
50
0
22
0
8
0
8
0
8
8
0
0
15
% I
% Lys:
8
8
0
50
0
15
50
0
15
8
8
8
8
8
8
% K
% Leu:
8
0
8
8
0
0
0
0
50
15
15
0
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
0
0
0
0
0
8
0
0
% N
% Pro:
0
8
0
15
8
8
0
8
8
0
0
50
0
15
0
% P
% Gln:
50
0
15
0
0
22
0
0
8
0
0
0
0
0
8
% Q
% Arg:
0
0
0
0
0
22
8
15
8
0
0
0
0
8
50
% R
% Ser:
0
0
0
8
0
8
0
8
0
0
0
0
0
0
0
% S
% Thr:
15
0
8
8
8
0
0
50
8
15
50
0
15
0
0
% T
% Val:
0
0
8
0
0
15
8
0
0
0
0
0
0
58
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _