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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP2D6
All Species:
17.58
Human Site:
T261
Identified Species:
55.24
UniProt:
P10635
Number Species:
7
Phosphosite Substitution
Charge Score:
0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P10635
NP_000097
497
55769
T261
L
L
T
E
H
R
M
T
W
D
P
A
Q
P
P
Chimpanzee
Pan troglodytes
Q2XNC8
497
55843
T261
L
L
T
E
H
R
M
T
W
D
P
A
Q
P
P
Rhesus Macaque
Macaca mulatta
NP_001035308
497
55924
T261
L
L
T
E
H
R
M
T
W
D
P
A
Q
P
P
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIM7
500
56957
T264
M
L
I
E
H
D
L
T
W
D
P
A
Q
P
P
Rat
Rattus norvegicus
P13108
500
56679
T264
L
L
T
E
H
K
V
T
W
D
P
A
Q
P
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_416219
502
57928
E266
M
L
I
D
K
H
K
E
T
W
N
P
A
Y
I
Frog
Xenopus laevis
NP_001087043
505
58104
Q269
E
I
I
K
D
H
Q
Q
T
W
D
S
G
H
T
Zebra Danio
Brachydanio rerio
NP_956433
496
56719
D262
R
V
K
E
H
R
V
D
Y
D
P
S
N
P
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
93.7
N.A.
N.A.
71
76.8
N.A.
N.A.
55.1
53.4
44.8
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.4
95.7
N.A.
N.A.
81.4
84.5
N.A.
N.A.
71.5
69.1
61.5
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
N.A.
N.A.
73.3
86.6
N.A.
N.A.
6.6
0
40
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
N.A.
N.A.
86.6
100
N.A.
N.A.
20
20
66.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
63
13
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
13
13
13
0
13
0
75
13
0
0
0
0
% D
% Glu:
13
0
0
75
0
0
0
13
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
13
0
0
% G
% His:
0
0
0
0
75
25
0
0
0
0
0
0
0
13
0
% H
% Ile:
0
13
38
0
0
0
0
0
0
0
0
0
0
0
13
% I
% Lys:
0
0
13
13
13
13
13
0
0
0
0
0
0
0
0
% K
% Leu:
50
75
0
0
0
0
13
0
0
0
0
0
0
0
0
% L
% Met:
25
0
0
0
0
0
38
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
13
0
13
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
75
13
0
75
63
% P
% Gln:
0
0
0
0
0
0
13
13
0
0
0
0
63
0
0
% Q
% Arg:
13
0
0
0
0
50
0
0
0
0
0
0
0
0
13
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
25
0
0
0
% S
% Thr:
0
0
50
0
0
0
0
63
25
0
0
0
0
0
13
% T
% Val:
0
13
0
0
0
0
25
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
63
25
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
13
0
0
0
0
13
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _