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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DLAT All Species: 13.33
Human Site: T347 Identified Species: 18.33
UniProt: P10515 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P10515 NP_001922.2 647 68997 T347 P S A P C P A T P A G P K G R
Chimpanzee Pan troglodytes XP_522180 647 68973 T347 P S A P C P A T P A G P K G R
Rhesus Macaque Macaca mulatta XP_001107013 647 68918 T347 P S A P C P A T P A G P K G R
Dog Lupus familis XP_546524 647 68802 T347 P S A P R P A T P A G P K G R
Cat Felis silvestris
Mouse Mus musculus Q8BMF4 642 67923 P346 P S A A P A G P K G R V F V S
Rat Rattus norvegicus P08461 632 67147 P337 P S A A P A G P K G R V F V S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509202 536 56600 L253 V S P L A R K L A T E K G I D
Chicken Gallus gallus XP_417933 681 72018 A376 P A A P P T P A V P T A G P P
Frog Xenopus laevis NP_001082239 628 66845 P324 A P T P S A A P S A P K G R V
Zebra Danio Brachydanio rerio NP_997832 652 69250 A347 A A P A A P A A A R K G R V F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609118 512 54233 A231 R V Y A S P M A K R L A E A Q
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q19749 507 53448 A226 R V S A S P F A K K L A A E N
Sea Urchin Strong. purpuratus XP_001190217 487 52117 A206 V T Q G R V F A S P L A R K L
Poplar Tree Populus trichocarpa XP_002303212 512 55370 E231 P L A R K L A E D H N V P L S
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q5M729 539 58449 E258 P L A R K L A E D N N V P L S
Baker's Yeast Sacchar. cerevisiae P12695 482 51800 G201 V H G T G P R G R I T K A D I
Red Bread Mold Neurospora crassa P20285 458 48601 N177 T A L E R E P N A L P A A K R
Conservation
Percent
Protein Identity: 100 99.2 98.1 89.4 N.A. 85.6 85.1 N.A. 70.3 72 72.8 71.9 N.A. 42 N.A. 41.7 39.8
Protein Similarity: 100 99.2 98.6 92.8 N.A. 90.2 89.6 N.A. 74.5 78.4 82.6 78.9 N.A. 53.9 N.A. 55 54.1
P-Site Identity: 100 100 100 93.3 N.A. 20 20 N.A. 6.6 20 20 13.3 N.A. 6.6 N.A. 6.6 0
P-Site Similarity: 100 100 100 93.3 N.A. 20 20 N.A. 6.6 26.6 20 26.6 N.A. 20 N.A. 13.3 13.3
Percent
Protein Identity: 36.3 N.A. N.A. 38.6 33.5 36.6
Protein Similarity: 50.2 N.A. N.A. 53 48.2 48.8
P-Site Identity: 20 N.A. N.A. 20 6.6 6.6
P-Site Similarity: 20 N.A. N.A. 20 6.6 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 18 53 30 12 18 48 30 18 30 0 30 18 6 0 % A
% Cys: 0 0 0 0 18 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 12 0 0 0 0 6 6 % D
% Glu: 0 0 0 6 0 6 0 12 0 0 6 0 6 6 0 % E
% Phe: 0 0 0 0 0 0 12 0 0 0 0 0 12 0 6 % F
% Gly: 0 0 6 6 6 0 12 6 0 12 24 6 18 24 0 % G
% His: 0 6 0 0 0 0 0 0 0 6 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 6 0 0 0 6 6 % I
% Lys: 0 0 0 0 12 0 6 0 24 6 6 18 24 12 0 % K
% Leu: 0 12 6 6 0 12 0 6 0 6 18 0 0 12 6 % L
% Met: 0 0 0 0 0 0 6 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 6 0 6 12 0 0 0 6 % N
% Pro: 53 6 12 36 18 48 12 18 24 12 12 24 12 6 6 % P
% Gln: 0 0 6 0 0 0 0 0 0 0 0 0 0 0 6 % Q
% Arg: 12 0 0 12 18 6 6 0 6 12 12 0 12 6 30 % R
% Ser: 0 42 6 0 18 0 0 0 12 0 0 0 0 0 24 % S
% Thr: 6 6 6 6 0 6 0 24 0 6 12 0 0 0 0 % T
% Val: 18 12 0 0 0 6 0 0 6 0 0 24 0 18 6 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 6 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _