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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GAA All Species: 29.39
Human Site: Y136 Identified Species: 58.79
UniProt: P10253 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P10253 NP_000143.2 952 105319 Y136 F P P S Y P S Y K L E N L S S
Chimpanzee Pan troglodytes XP_001160562 952 105395 Y136 F P P S Y P S Y K L E N L S S
Rhesus Macaque Macaca mulatta XP_001109939 952 105411 Y136 F P P S Y P S Y K L E N L S A
Dog Lupus familis XP_850649 951 105652 Y136 F P P S Y P S Y K L E N L T T
Cat Felis silvestris
Mouse Mus musculus P70699 953 106229 Y136 F P P S Y P S Y R L E N L S S
Rat Rattus norvegicus Q6P7A9 953 106188 Y136 F P P S Y P S Y R L E N L S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001232641 930 104640 Y132 Y P P S F P S Y V V Q S L N Q
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001921957 882 99143 R106 S A P S Y L P R D I H T L Q L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392880 865 100033 L89 S A I D N S I L R I K I Y D A
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_787183 1049 116156 Y240 Y P L D Y P G Y V N G V P T P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9S7Y7 915 102380 T120 K S R K S P I T V Q E I S G S
Baker's Yeast Sacchar. cerevisiae P38138 954 110248 Q156 F H F L K Q K Q T V N S F W S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.5 95.4 83.9 N.A. 80 81.3 N.A. N.A. 50.4 N.A. 53.2 N.A. N.A. 37.7 N.A. 43
Protein Similarity: 100 98.9 97.6 89.5 N.A. 88.4 88.2 N.A. N.A. 66 N.A. 67.7 N.A. N.A. 53.1 N.A. 56.8
P-Site Identity: 100 100 93.3 86.6 N.A. 93.3 93.3 N.A. N.A. 46.6 N.A. 26.6 N.A. N.A. 0 N.A. 26.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 86.6 N.A. 33.3 N.A. N.A. 26.6 N.A. 40
Percent
Protein Identity: N.A. N.A. N.A. 32.7 23 N.A.
Protein Similarity: N.A. N.A. N.A. 50.5 43.7 N.A.
P-Site Identity: N.A. N.A. N.A. 20 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 17 0 0 0 0 0 0 0 0 0 0 0 0 17 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 17 0 0 0 0 9 0 0 0 0 9 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 59 0 0 0 0 % E
% Phe: 59 0 9 0 9 0 0 0 0 0 0 0 9 0 0 % F
% Gly: 0 0 0 0 0 0 9 0 0 0 9 0 0 9 0 % G
% His: 0 9 0 0 0 0 0 0 0 0 9 0 0 0 0 % H
% Ile: 0 0 9 0 0 0 17 0 0 17 0 17 0 0 0 % I
% Lys: 9 0 0 9 9 0 9 0 34 0 9 0 0 0 0 % K
% Leu: 0 0 9 9 0 9 0 9 0 50 0 0 67 0 9 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 9 0 0 0 0 9 9 50 0 9 0 % N
% Pro: 0 67 67 0 0 75 9 0 0 0 0 0 9 0 9 % P
% Gln: 0 0 0 0 0 9 0 9 0 9 9 0 0 9 9 % Q
% Arg: 0 0 9 0 0 0 0 9 25 0 0 0 0 0 0 % R
% Ser: 17 9 0 67 9 9 59 0 0 0 0 17 9 42 50 % S
% Thr: 0 0 0 0 0 0 0 9 9 0 0 9 0 17 9 % T
% Val: 0 0 0 0 0 0 0 0 25 17 0 9 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % W
% Tyr: 17 0 0 0 67 0 0 67 0 0 0 0 9 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _