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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GAA All Species: 16.97
Human Site: S45 Identified Species: 33.94
UniProt: P10253 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P10253 NP_000143.2 952 105319 S45 V P R E L S G S S P V L E E T
Chimpanzee Pan troglodytes XP_001160562 952 105395 S45 V P R E L S G S S S V L E E T
Rhesus Macaque Macaca mulatta XP_001109939 952 105411 S45 V P R E L S G S S S V L E E T
Dog Lupus familis XP_850649 951 105652 F45 A P Q E Q R R F S Q G P E Q L
Cat Felis silvestris
Mouse Mus musculus P70699 953 106229 S45 L P Q D L H E S S S G L W K T
Rat Rattus norvegicus Q6P7A9 953 106188 S45 L P Q D L H E S S S G L W K T
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001232641 930 104640 G44 A P W W V G S G L L I T A V L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001921957 882 99143 S26 G R R R E G N S D Q C G I A V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392880 865 100033 P9 D E Q C D N I P V T L R F D C
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_787183 1049 116156 A84 P S L D V S G A L G L S E K D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9S7Y7 915 102380 I40 K G Y R L V S I E E S P D G G
Baker's Yeast Sacchar. cerevisiae P38138 954 110248 T76 L H A T I I K T I P R L E G D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.5 95.4 83.9 N.A. 80 81.3 N.A. N.A. 50.4 N.A. 53.2 N.A. N.A. 37.7 N.A. 43
Protein Similarity: 100 98.9 97.6 89.5 N.A. 88.4 88.2 N.A. N.A. 66 N.A. 67.7 N.A. N.A. 53.1 N.A. 56.8
P-Site Identity: 100 93.3 93.3 26.6 N.A. 40 40 N.A. N.A. 6.6 N.A. 13.3 N.A. N.A. 0 N.A. 20
P-Site Similarity: 100 93.3 93.3 40 N.A. 66.6 66.6 N.A. N.A. 20 N.A. 13.3 N.A. N.A. 26.6 N.A. 53.3
Percent
Protein Identity: N.A. N.A. N.A. 32.7 23 N.A.
Protein Similarity: N.A. N.A. N.A. 50.5 43.7 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 20 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 17 0 9 0 0 0 0 9 0 0 0 0 9 9 0 % A
% Cys: 0 0 0 9 0 0 0 0 0 0 9 0 0 0 9 % C
% Asp: 9 0 0 25 9 0 0 0 9 0 0 0 9 9 17 % D
% Glu: 0 9 0 34 9 0 17 0 9 9 0 0 50 25 0 % E
% Phe: 0 0 0 0 0 0 0 9 0 0 0 0 9 0 0 % F
% Gly: 9 9 0 0 0 17 34 9 0 9 25 9 0 17 9 % G
% His: 0 9 0 0 0 17 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 9 9 9 9 9 0 9 0 9 0 0 % I
% Lys: 9 0 0 0 0 0 9 0 0 0 0 0 0 25 0 % K
% Leu: 25 0 9 0 50 0 0 0 17 9 17 50 0 0 17 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 9 9 0 0 0 0 0 0 0 0 % N
% Pro: 9 59 0 0 0 0 0 9 0 17 0 17 0 0 0 % P
% Gln: 0 0 34 0 9 0 0 0 0 17 0 0 0 9 0 % Q
% Arg: 0 9 34 17 0 9 9 0 0 0 9 9 0 0 0 % R
% Ser: 0 9 0 0 0 34 17 50 50 34 9 9 0 0 0 % S
% Thr: 0 0 0 9 0 0 0 9 0 9 0 9 0 0 42 % T
% Val: 25 0 0 0 17 9 0 0 9 0 25 0 0 9 9 % V
% Trp: 0 0 9 9 0 0 0 0 0 0 0 0 17 0 0 % W
% Tyr: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _