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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FURIN
All Species:
40.61
Human Site:
S421
Identified Species:
74.44
UniProt:
P09958
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P09958
NP_002560.1
794
86678
S421
N
G
V
G
R
K
V
S
H
S
Y
G
Y
G
L
Chimpanzee
Pan troglodytes
XP_510596
794
86649
S421
N
G
V
G
R
K
V
S
H
S
Y
G
Y
G
L
Rhesus Macaque
Macaca mulatta
XP_001094068
794
86687
S421
N
G
V
G
R
K
V
S
H
S
Y
G
Y
G
L
Dog
Lupus familis
XP_850069
801
87503
S421
N
G
V
G
R
K
V
S
H
S
Y
G
Y
G
L
Cat
Felis silvestris
Mouse
Mus musculus
P23188
793
86786
S421
N
G
V
G
R
K
V
S
H
S
Y
G
Y
G
L
Rat
Rattus norvegicus
P23377
793
86635
S421
N
G
V
G
R
K
V
S
H
S
Y
G
Y
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_990046
789
86613
S422
N
G
V
G
R
K
V
S
H
S
Y
G
Y
G
L
Frog
Xenopus laevis
P29119
783
86425
S419
N
G
V
G
R
K
V
S
H
S
Y
G
Y
G
L
Zebra Danio
Brachydanio rerio
NP_001038574
823
89738
S422
N
G
V
G
R
L
V
S
H
S
Y
G
Y
G
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P26016
1269
138609
S640
N
G
V
G
R
R
V
S
H
S
F
G
Y
G
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P51559
943
103128
V468
R
N
G
V
G
R
M
V
S
N
K
F
G
Y
G
Sea Urchin
Strong. purpuratus
XP_780373
746
81468
A387
P
L
A
A
G
I
C
A
L
A
L
E
A
N
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
H440
A
M
G
K
K
Y
S
H
R
Y
G
F
G
K
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.8
93.5
N.A.
93.6
93.6
N.A.
N.A.
79.8
70.2
63.7
N.A.
32.5
N.A.
37.4
48.9
Protein Similarity:
100
99.7
99.2
95
N.A.
95.7
95.2
N.A.
N.A.
86.4
80.8
75
N.A.
42.7
N.A.
50.2
61.2
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
100
93.3
N.A.
86.6
N.A.
0
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
100
93.3
N.A.
100
N.A.
20
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
46.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
8
0
0
0
8
0
8
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
8
16
0
0
0
% F
% Gly:
0
77
16
77
16
0
0
0
0
0
8
77
16
77
8
% G
% His:
0
0
0
0
0
0
0
8
77
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
8
% I
% Lys:
0
0
0
8
8
62
0
0
0
0
8
0
0
8
0
% K
% Leu:
0
8
0
0
0
8
0
0
8
0
8
0
0
0
77
% L
% Met:
0
8
0
0
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
77
8
0
0
0
0
0
0
0
8
0
0
0
8
0
% N
% Pro:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
8
0
0
0
77
16
0
0
8
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
8
77
8
77
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
77
8
0
0
77
8
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
0
8
70
0
77
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _