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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLA1 All Species: 37.58
Human Site: Y1146 Identified Species: 75.15
UniProt: P09884 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P09884 NP_058633.2 1462 165913 Y1146 L T K D P Q D Y P D K K S L P
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001091195 1462 165768 Y1146 L T K D P Q D Y P D K K S L P
Dog Lupus familis XP_537985 1590 179675 Y1152 L T K D P Q D Y P D K K S L P
Cat Felis silvestris
Mouse Mus musculus P33609 1465 167321 Y1150 L T K D P Q D Y P D R K S L P
Rat Rattus norvegicus O89042 1451 165288 D1149 I N K A L T K D P Q D Y P D K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_416792 1496 170879 Y1170 L T K D P Q D Y P D K K S L P
Frog Xenopus laevis Q9DE46 1458 165042 Y1142 L T K D P Q D Y P D K K S L P
Zebra Danio Brachydanio rerio XP_001922054 1470 166510 Y1155 L T K E P Q D Y P D K K S L P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P26019 1488 169885 Y1156 L T R T P Q E Y A N S A S L P
Honey Bee Apis mellifera XP_001121438 1239 142457 S937 K I L D H L L S N Q P C E D R
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FHA3 1492 167126 Y1189 L T K P P A A Y P D S K S Q P
Baker's Yeast Sacchar. cerevisiae P13382 1468 166791 Y1140 L S K D P K A Y P G G K N M P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 97.7 84.4 N.A. 88 89 N.A. N.A. 73.8 72.5 68.9 N.A. 40 39.4 N.A. N.A.
Protein Similarity: 100 N.A. 99 87.9 N.A. 92.4 93 N.A. N.A. 84.8 84.1 82.1 N.A. 58.7 56.1 N.A. N.A.
P-Site Identity: 100 N.A. 100 100 N.A. 93.3 13.3 N.A. N.A. 100 100 93.3 N.A. 53.3 6.6 N.A. N.A.
P-Site Similarity: 100 N.A. 100 100 N.A. 100 20 N.A. N.A. 100 100 100 N.A. 73.3 6.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 34.8 32.2 N.A.
Protein Similarity: N.A. N.A. N.A. 54.8 52.2 N.A.
P-Site Identity: N.A. N.A. N.A. 66.6 53.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 66.6 80 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 9 0 9 17 0 9 0 0 9 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % C
% Asp: 0 0 0 67 0 0 59 9 0 67 9 0 0 17 0 % D
% Glu: 0 0 0 9 0 0 9 0 0 0 0 0 9 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 9 9 0 0 0 0 % G
% His: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 9 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 9 0 84 0 0 9 9 0 0 0 50 75 0 0 9 % K
% Leu: 84 0 9 0 9 9 9 0 0 0 0 0 0 67 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % M
% Asn: 0 9 0 0 0 0 0 0 9 9 0 0 9 0 0 % N
% Pro: 0 0 0 9 84 0 0 0 84 0 9 0 9 0 84 % P
% Gln: 0 0 0 0 0 67 0 0 0 17 0 0 0 9 0 % Q
% Arg: 0 0 9 0 0 0 0 0 0 0 9 0 0 0 9 % R
% Ser: 0 9 0 0 0 0 0 9 0 0 17 0 75 0 0 % S
% Thr: 0 75 0 9 0 9 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 84 0 0 0 9 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _