Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDHA1 All Species: 44.55
Human Site: Y65 Identified Species: 75.38
UniProt: P08559 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P08559 NP_000275.1 390 43296 Y65 R E D G L K Y Y R M M Q T V R
Chimpanzee Pan troglodytes A5A6L0 390 43219 Y65 R E D G L K Y Y R M M Q T V R
Rhesus Macaque Macaca mulatta XP_001097880 420 46631 Y95 R A E G L K Y Y R M M L T V R
Dog Lupus familis XP_537975 390 43375 Y65 R E D G L R Y Y R M M Q T V R
Cat Felis silvestris
Mouse Mus musculus P35486 390 43213 Y65 R E D G L K Y Y R M M Q T V R
Rat Rattus norvegicus P26284 390 43208 Y65 R E D G L K Y Y R M M Q T V R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514100 568 62886 Y243 R E E G L K Y Y R T M Q T I R
Chicken Gallus gallus NP_001012562 399 44424 Y72 R E E G L H Y Y K T M Q T I R
Frog Xenopus laevis NP_001087610 400 44764 Y75 R E E G L Q Y Y R T M Q T I R
Zebra Danio Brachydanio rerio NP_998558 393 43722 Y68 R E E G L Q Y Y R T M Q T M R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P52899 397 43773 I65 Y Y R D M Q V I R R M E S A A
Sea Urchin Strong. purpuratus XP_001175746 386 42313 Y63 K D E A L D Y Y H K M Q T I R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P52901 389 43041 F63 S Q E L L D F F R T M A L M R
Baker's Yeast Sacchar. cerevisiae P16387 420 46325 Y85 K A T L L Q M Y K D M V I I R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 79 98.9 N.A. 98.2 97.9 N.A. 63.7 84.7 82 80.1 N.A. N.A. N.A. 58.9 59.7
Protein Similarity: 100 99.7 85 99.7 N.A. 99.4 99.2 N.A. 67 91.2 92.2 90 N.A. N.A. N.A. 71.7 74.1
P-Site Identity: 100 100 80 93.3 N.A. 100 100 N.A. 80 66.6 73.3 73.3 N.A. N.A. N.A. 13.3 46.6
P-Site Similarity: 100 100 86.6 100 N.A. 100 100 N.A. 93.3 86.6 93.3 93.3 N.A. N.A. N.A. 40 73.3
Percent
Protein Identity: N.A. N.A. N.A. 48.9 46.9 N.A.
Protein Similarity: N.A. N.A. N.A. 66.4 63.1 N.A.
P-Site Identity: N.A. N.A. N.A. 26.6 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 60 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 15 0 8 0 0 0 0 0 0 0 8 0 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 36 8 0 15 0 0 0 8 0 0 0 0 0 % D
% Glu: 0 65 50 0 0 0 0 0 0 0 0 8 0 0 0 % E
% Phe: 0 0 0 0 0 0 8 8 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 72 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 8 0 0 8 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 8 0 0 0 0 8 36 0 % I
% Lys: 15 0 0 0 0 43 0 0 15 8 0 0 0 0 0 % K
% Leu: 0 0 0 15 93 0 0 0 0 0 0 8 8 0 0 % L
% Met: 0 0 0 0 8 0 8 0 0 43 100 0 0 15 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 8 0 0 0 29 0 0 0 0 0 72 0 0 0 % Q
% Arg: 72 0 8 0 0 8 0 0 79 8 0 0 0 0 93 % R
% Ser: 8 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % S
% Thr: 0 0 8 0 0 0 0 0 0 36 0 0 79 0 0 % T
% Val: 0 0 0 0 0 0 8 0 0 0 0 8 0 43 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 8 0 0 0 0 79 86 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _