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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ABCB1
All Species:
46.06
Human Site:
Y277
Identified Species:
84.44
UniProt:
P08183
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08183
NP_000918.2
1280
141479
Y277
Q
K
K
E
L
E
R
Y
N
K
N
L
E
E
A
Chimpanzee
Pan troglodytes
XP_519183
1280
141455
Y277
Q
K
K
E
L
E
R
Y
N
K
N
L
E
E
A
Rhesus Macaque
Macaca mulatta
NP_001028059
1283
141504
Y280
Q
K
K
E
L
E
R
Y
N
K
N
L
E
E
A
Dog
Lupus familis
XP_539461
1269
140189
Y269
Q
E
K
E
I
Q
R
Y
T
Q
N
L
K
D
A
Cat
Felis silvestris
Mouse
Mus musculus
P21447
1276
140628
Y273
Q
K
K
E
L
E
R
Y
N
N
N
L
E
E
A
Rat
Rattus norvegicus
P43245
1277
141369
Y276
Q
K
K
E
L
E
R
Y
N
K
N
L
E
E
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508941
1368
147746
Y371
Q
S
K
E
L
A
R
Y
K
R
H
L
E
E
A
Chicken
Gallus gallus
XP_418636
1307
144961
Y308
Q
R
K
E
T
E
R
Y
Q
K
N
L
E
D
A
Frog
Xenopus laevis
NP_001081394
1287
141487
Y287
Q
N
K
E
I
H
R
Y
E
K
N
L
E
D
A
Zebra Danio
Brachydanio rerio
XP_001922717
1340
147081
Y321
Q
K
K
A
V
E
K
Y
E
K
N
L
V
E
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q00748
1302
143766
Y283
E
K
S
E
V
Q
R
Y
E
N
F
L
V
P
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34712
1321
145045
Y301
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O80725
1286
139009
Y269
E
K
Q
A
I
S
N
Y
N
K
H
L
V
T
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
96
55.7
N.A.
87.1
80.6
N.A.
62.1
69.6
67.6
56
N.A.
41.1
N.A.
44.5
N.A.
Protein Similarity:
100
99.8
97.7
75.4
N.A.
93.3
90.1
N.A.
76.6
83.6
81.8
73.5
N.A.
60.4
N.A.
62.6
N.A.
P-Site Identity:
100
100
100
53.3
N.A.
93.3
100
N.A.
66.6
73.3
66.6
66.6
N.A.
40
N.A.
53.3
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
100
N.A.
80
86.6
80
80
N.A.
60
N.A.
73.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.2
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
16
0
8
0
0
0
0
8
0
0
0
100
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
24
0
% D
% Glu:
16
8
0
85
0
62
0
0
24
0
0
0
70
62
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
8
0
0
0
0
16
0
0
0
0
% H
% Ile:
0
0
0
0
24
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
62
77
0
0
0
8
0
8
62
0
0
8
0
0
% K
% Leu:
8
0
0
0
54
0
0
0
0
0
0
93
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
0
8
0
47
16
70
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% P
% Gln:
77
0
8
0
0
16
0
0
8
8
0
0
0
0
0
% Q
% Arg:
0
16
0
0
0
0
85
0
0
8
0
0
0
0
0
% R
% Ser:
0
8
8
0
0
8
0
0
8
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
8
0
0
0
8
8
0
0
0
8
0
% T
% Val:
0
0
0
0
16
0
0
0
0
0
0
8
24
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
100
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _