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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CTSD All Species: 30.61
Human Site: Y393 Identified Species: 61.21
UniProt: P07339 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P07339 NP_001900.1 412 44552 Y393 G D V F I G R Y Y T V F D R D
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta P11489 388 41678 F375 I R Q Y F T V F D R A N N Q V
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P18242 410 44935 Y391 G D V F I G S Y Y T V F D R D
Rat Rattus norvegicus P24268 407 44662 Y388 G D V F I G C Y Y T V F D R E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q05744 398 43280 Y381 G D V F I G P Y Y T V F D R D
Frog Xenopus laevis Q805F3 397 42889 Y371 G D V F I G Q Y Y S V F D R G
Zebra Danio Brachydanio rerio NP_571785 399 43486 Y380 G D V F I G Q Y Y T V F D R E
Tiger Blowfish Takifugu rubipres NP_001072052 396 43134 Y379 G D V F I G Q Y Y T V F D R D
Fruit Fly Dros. melanogaster NP_652013 392 42454 Y375 G D V F I G K Y Y T E F D M G
Honey Bee Apis mellifera XP_392857 385 42204 G375 Y Y T E F D M G N N R V G F A
Nematode Worm Caenorhab. elegans P55956 398 43395 F378 G D V F I G R F Y S V F D H G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q01294 396 42914 Y382 L R K Y Y S I Y D L G A D T V
Conservation
Percent
Protein Identity: 100 N.A. 45.3 N.A. N.A. 80.8 81.8 N.A. N.A. 67.2 45.3 64 66.7 52.9 55.3 44.9 N.A.
Protein Similarity: 100 N.A. 60.4 N.A. N.A. 89 89.3 N.A. N.A. 79.6 64.5 77.4 79.3 68.9 68.9 59.9 N.A.
P-Site Identity: 100 N.A. 0 N.A. N.A. 93.3 86.6 N.A. N.A. 93.3 80 86.6 93.3 73.3 0 73.3 N.A.
P-Site Similarity: 100 N.A. 26.6 N.A. N.A. 93.3 93.3 N.A. N.A. 93.3 93.3 100 100 80 0 86.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 41.7
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 58.5
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 9 9 0 0 9 % A
% Cys: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % C
% Asp: 0 75 0 0 0 9 0 0 17 0 0 0 84 0 34 % D
% Glu: 0 0 0 9 0 0 0 0 0 0 9 0 0 0 17 % E
% Phe: 0 0 0 75 17 0 0 17 0 0 0 75 0 9 0 % F
% Gly: 75 0 0 0 0 75 0 9 0 0 9 0 9 0 25 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % H
% Ile: 9 0 0 0 75 0 9 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 9 0 0 0 9 0 0 0 0 0 0 0 0 % K
% Leu: 9 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 9 0 0 0 0 0 0 9 0 % M
% Asn: 0 0 0 0 0 0 0 0 9 9 0 9 9 0 0 % N
% Pro: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 9 0 0 0 25 0 0 0 0 0 0 9 0 % Q
% Arg: 0 17 0 0 0 0 17 0 0 9 9 0 0 59 0 % R
% Ser: 0 0 0 0 0 9 9 0 0 17 0 0 0 0 0 % S
% Thr: 0 0 9 0 0 9 0 0 0 59 0 0 0 9 0 % T
% Val: 0 0 75 0 0 0 9 0 0 0 67 9 0 0 17 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 9 0 17 9 0 0 75 75 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _