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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSD
All Species:
10.61
Human Site:
T250
Identified Species:
21.21
UniProt:
P07339
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P07339
NP_001900.1
412
44552
T250
G
E
L
M
L
G
G
T
D
S
K
Y
Y
K
G
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
P11489
388
41678
N242
S
Y
Y
T
G
S
L
N
W
V
P
V
S
V
E
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P18242
410
44935
T248
G
E
L
M
L
G
G
T
D
S
K
Y
Y
H
G
Rat
Rattus norvegicus
P24268
407
44662
T245
G
E
L
M
L
G
G
T
D
S
R
Y
Y
H
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q05744
398
43280
S244
G
T
D
P
K
Y
Y
S
G
D
F
S
W
V
N
Frog
Xenopus laevis
Q805F3
397
42889
G239
F
D
A
S
R
F
S
G
Q
L
N
W
V
P
V
Zebra Danio
Brachydanio rerio
NP_571785
399
43486
D248
T
G
D
F
N
Y
V
D
I
S
R
Q
A
Y
W
Tiger Blowfish
Takifugu rubipres
NP_001072052
396
43134
Y247
Y
Y
T
G
D
F
D
Y
V
N
V
T
R
Q
A
Fruit Fly
Dros. melanogaster
NP_652013
392
42454
T243
N
H
Y
T
G
E
F
T
Y
L
P
V
T
R
K
Honey Bee
Apis mellifera
XP_392857
385
42204
G243
Y
V
P
V
D
K
K
G
Y
W
Q
F
R
M
D
Nematode Worm
Caenorhab. elegans
P55956
398
43395
A245
N
H
Y
V
G
N
I
A
W
E
P
L
V
S
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q01294
396
42914
K248
N
K
D
R
Y
T
G
K
I
T
T
I
P
L
R
Conservation
Percent
Protein Identity:
100
N.A.
45.3
N.A.
N.A.
80.8
81.8
N.A.
N.A.
67.2
45.3
64
66.7
52.9
55.3
44.9
N.A.
Protein Similarity:
100
N.A.
60.4
N.A.
N.A.
89
89.3
N.A.
N.A.
79.6
64.5
77.4
79.3
68.9
68.9
59.9
N.A.
P-Site Identity:
100
N.A.
0
N.A.
N.A.
93.3
86.6
N.A.
N.A.
6.6
0
6.6
0
6.6
0
0
N.A.
P-Site Similarity:
100
N.A.
0
N.A.
N.A.
93.3
93.3
N.A.
N.A.
20
13.3
13.3
13.3
13.3
20
6.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
41.7
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
58.5
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
0
0
0
0
9
0
0
0
0
9
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
25
0
17
0
9
9
25
9
0
0
0
0
9
% D
% Glu:
0
25
0
0
0
9
0
0
0
9
0
0
0
0
17
% E
% Phe:
9
0
0
9
0
17
9
0
0
0
9
9
0
0
0
% F
% Gly:
34
9
0
9
25
25
34
17
9
0
0
0
0
0
25
% G
% His:
0
17
0
0
0
0
0
0
0
0
0
0
0
17
0
% H
% Ile:
0
0
0
0
0
0
9
0
17
0
0
9
0
0
0
% I
% Lys:
0
9
0
0
9
9
9
9
0
0
17
0
0
9
9
% K
% Leu:
0
0
25
0
25
0
9
0
0
17
0
9
0
9
0
% L
% Met:
0
0
0
25
0
0
0
0
0
0
0
0
0
9
0
% M
% Asn:
25
0
0
0
9
9
0
9
0
9
9
0
0
0
9
% N
% Pro:
0
0
9
9
0
0
0
0
0
0
25
0
9
9
0
% P
% Gln:
0
0
0
0
0
0
0
0
9
0
9
9
0
9
0
% Q
% Arg:
0
0
0
9
9
0
0
0
0
0
17
0
17
9
9
% R
% Ser:
9
0
0
9
0
9
9
9
0
34
0
9
9
9
0
% S
% Thr:
9
9
9
17
0
9
0
34
0
9
9
9
9
0
0
% T
% Val:
0
9
0
17
0
0
9
0
9
9
9
17
17
17
9
% V
% Trp:
0
0
0
0
0
0
0
0
17
9
0
9
9
0
9
% W
% Tyr:
17
17
25
0
9
17
9
9
17
0
0
25
25
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _