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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CSF1R All Species: 11.21
Human Site: S178 Identified Species: 24.67
UniProt: P07333 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.3
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P07333 NP_005202.2 972 107984 S178 Q S Q D Y Q C S A L M G G R K
Chimpanzee Pan troglodytes XP_517285 1073 120068 C284 K R A Y H R L C L H C S V D Q
Rhesus Macaque Macaca mulatta XP_001107833 976 108270 S178 Q G Q D Y Q C S A L M G S R K
Dog Lupus familis XP_546306 967 107148 S178 E T Q G Y Q C S A R V G G R T
Cat Felis silvestris
Mouse Mus musculus P09581 977 109161 K178 D S N T Y V C K T M V N G R E
Rat Rattus norvegicus Q00495 978 109246 K178 D S N T Y V C K T M V N G R E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506832 966 107509 S171 I I K S V Q R S Y N K V C F Q
Chicken Gallus gallus Q08156 960 107293 S168 I I K N V Q R S F K G C Y Q C
Frog Xenopus laevis Q91909 954 106841 Q172 G I T I K T V Q L A F D S C Y
Zebra Danio Brachydanio rerio Q9I8N6 977 110169 R169 M N I T Y D P R K G V L I R N
Tiger Blowfish Takifugu rubipres P79750 975 110895 S182 L I R S L Q P S F N A D Y V C
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 37.3 95.6 84.3 N.A. 75.1 74.7 N.A. 40.7 39.2 39.2 45 43.6 N.A. N.A. N.A. N.A.
Protein Similarity: 100 52.7 97.2 88.7 N.A. 83.2 82.8 N.A. 56.3 56.3 56.3 61.1 60.3 N.A. N.A. N.A. N.A.
P-Site Identity: 100 0 86.6 60 N.A. 33.3 33.3 N.A. 13.3 13.3 0 13.3 13.3 N.A. N.A. N.A. N.A.
P-Site Similarity: 100 26.6 86.6 80 N.A. 53.3 53.3 N.A. 26.6 33.3 0 26.6 20 N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 0 0 0 0 0 28 10 10 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 46 10 0 0 10 10 10 10 19 % C
% Asp: 19 0 0 19 0 10 0 0 0 0 0 19 0 10 0 % D
% Glu: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 19 % E
% Phe: 0 0 0 0 0 0 0 0 19 0 10 0 0 10 0 % F
% Gly: 10 10 0 10 0 0 0 0 0 10 10 28 37 0 0 % G
% His: 0 0 0 0 10 0 0 0 0 10 0 0 0 0 0 % H
% Ile: 19 37 10 10 0 0 0 0 0 0 0 0 10 0 0 % I
% Lys: 10 0 19 0 10 0 0 19 10 10 10 0 0 0 19 % K
% Leu: 10 0 0 0 10 0 10 0 19 19 0 10 0 0 0 % L
% Met: 10 0 0 0 0 0 0 0 0 19 19 0 0 0 0 % M
% Asn: 0 10 19 10 0 0 0 0 0 19 0 19 0 0 10 % N
% Pro: 0 0 0 0 0 0 19 0 0 0 0 0 0 0 0 % P
% Gln: 19 0 28 0 0 55 0 10 0 0 0 0 0 10 19 % Q
% Arg: 0 10 10 0 0 10 19 10 0 10 0 0 0 55 0 % R
% Ser: 0 28 0 19 0 0 0 55 0 0 0 10 19 0 0 % S
% Thr: 0 10 10 28 0 10 0 0 19 0 0 0 0 0 10 % T
% Val: 0 0 0 0 19 19 10 0 0 0 37 10 10 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 10 55 0 0 0 10 0 0 0 19 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _