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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HEXA
All Species:
37.88
Human Site:
Y463
Identified Species:
69.44
UniProt:
P06865
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P06865
NP_000511.2
529
60689
Y463
E
A
C
M
W
G
E
Y
V
D
N
T
N
L
V
Chimpanzee
Pan troglodytes
XP_001175122
529
60636
Y463
E
A
C
M
W
G
E
Y
V
D
N
T
N
L
V
Rhesus Macaque
Macaca mulatta
XP_001092589
529
60742
Y463
E
A
C
M
W
G
E
Y
V
D
N
T
N
L
V
Dog
Lupus familis
XP_544758
529
60532
Y463
E
A
C
M
W
G
E
Y
V
D
S
T
N
L
A
Cat
Felis silvestris
Mouse
Mus musculus
P29416
528
60581
Y462
E
A
C
M
W
G
E
Y
V
D
S
T
N
L
V
Rat
Rattus norvegicus
Q641X3
528
60520
Y462
E
A
C
M
W
G
E
Y
V
D
S
T
N
L
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513475
574
64498
Y508
E
A
C
M
W
G
E
Y
V
D
A
T
N
L
T
Chicken
Gallus gallus
NP_001025561
526
58930
Y460
E
A
C
M
W
G
E
Y
V
D
V
T
N
L
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001017763
532
60708
Y465
E
V
A
M
W
G
E
Y
V
D
A
T
N
L
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q8WSF3
660
75468
Q588
E
V
C
M
W
T
E
Q
V
D
E
N
Q
L
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q22492
555
64361
L480
I
A
A
I
W
G
E
L
V
D
N
T
N
I
E
Sea Urchin
Strong. purpuratus
XP_799340
543
61806
Y477
E
V
C
M
W
G
E
Y
V
D
S
T
N
V
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001142218
433
49746
A385
W
P
R
A
G
A
I
A
E
R
L
W
S
S
N
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
97.7
81.8
N.A.
84.1
82.8
N.A.
54.5
66.1
N.A.
55.2
N.A.
27.7
N.A.
38.3
49.3
Protein Similarity:
100
99.8
99.2
90.7
N.A.
91.1
90.3
N.A.
66.7
78
N.A.
69.9
N.A.
41.6
N.A.
54.2
64.4
P-Site Identity:
100
100
100
86.6
N.A.
93.3
93.3
N.A.
86.6
86.6
N.A.
73.3
N.A.
53.3
N.A.
60
73.3
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
86.6
86.6
N.A.
73.3
N.A.
53.3
N.A.
73.3
93.3
Percent
Protein Identity:
N.A.
70.7
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
77.3
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
70
16
8
0
8
0
8
0
0
16
0
0
0
8
% A
% Cys:
0
0
77
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
93
0
0
0
0
8
% D
% Glu:
85
0
0
0
0
0
93
0
8
0
8
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
8
85
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
8
0
0
8
0
0
0
0
0
0
8
8
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
8
0
0
8
0
0
77
0
% L
% Met:
0
0
0
85
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
31
8
85
0
16
% N
% Pro:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
8
0
0
0
0
8
0
0
% Q
% Arg:
0
0
8
0
0
0
0
0
0
8
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
31
0
8
8
0
% S
% Thr:
0
0
0
0
0
8
0
0
0
0
0
85
0
0
16
% T
% Val:
0
24
0
0
0
0
0
0
93
0
8
0
0
8
39
% V
% Trp:
8
0
0
0
93
0
0
0
0
0
0
8
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
77
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _