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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HEXA All Species: 16.36
Human Site: Y227 Identified Species: 30
UniProt: P06865 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P06865 NP_000511.2 529 60689 Y227 E L M R K G S Y N P V T H I Y
Chimpanzee Pan troglodytes XP_001175122 529 60636 Y227 E L M R K G S Y N P V T H I Y
Rhesus Macaque Macaca mulatta XP_001092589 529 60742 Y227 E L M R K G S Y N P V T H I Y
Dog Lupus familis XP_544758 529 60532 Y227 E L T R K G S Y N P A T H I Y
Cat Felis silvestris
Mouse Mus musculus P29416 528 60581 F227 E L T R K G S F N P V T H I Y
Rat Rattus norvegicus Q641X3 528 60520 F227 E L T R K G S F N P V T H I Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513475 574 64498 S275 P E L S N Q G S Y S H S H V Y
Chicken Gallus gallus NP_001025561 526 58930 F226 E L S K Q G A F N A M T H V Y
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001017763 532 60708 F232 D L S K K G A F H P F T H I Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q8WSF3 660 75468 Y336 E L A V H G A Y S E S E T Y S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q22492 555 64361 A229 P E L H G V G A Y S P R H V Y
Sea Urchin Strong. purpuratus XP_799340 543 61806 N245 Y P S L S R M N A Y D Q N H V
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001142218 433 49746 E161 R G I R V L A E F D T P G H T
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 97.7 81.8 N.A. 84.1 82.8 N.A. 54.5 66.1 N.A. 55.2 N.A. 27.7 N.A. 38.3 49.3
Protein Similarity: 100 99.8 99.2 90.7 N.A. 91.1 90.3 N.A. 66.7 78 N.A. 69.9 N.A. 41.6 N.A. 54.2 64.4
P-Site Identity: 100 100 100 86.6 N.A. 86.6 86.6 N.A. 13.3 46.6 N.A. 53.3 N.A. 26.6 N.A. 13.3 0
P-Site Similarity: 100 100 100 86.6 N.A. 93.3 93.3 N.A. 33.3 86.6 N.A. 86.6 N.A. 40 N.A. 26.6 6.6
Percent
Protein Identity: N.A. 70.7 N.A. N.A. N.A. N.A.
Protein Similarity: N.A. 77.3 N.A. N.A. N.A. N.A.
P-Site Identity: N.A. 6.6 N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. 20 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 0 0 31 8 8 8 8 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 0 0 0 0 0 0 8 8 0 0 0 0 % D
% Glu: 62 16 0 0 0 0 0 8 0 8 0 8 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 31 8 0 8 0 0 0 0 % F
% Gly: 0 8 0 0 8 70 16 0 0 0 0 0 8 0 0 % G
% His: 0 0 0 8 8 0 0 0 8 0 8 0 77 16 0 % H
% Ile: 0 0 8 0 0 0 0 0 0 0 0 0 0 54 0 % I
% Lys: 0 0 0 16 54 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 70 16 8 0 8 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 24 0 0 0 8 0 0 0 8 0 0 0 0 % M
% Asn: 0 0 0 0 8 0 0 8 54 0 0 0 8 0 0 % N
% Pro: 16 8 0 0 0 0 0 0 0 54 8 8 0 0 0 % P
% Gln: 0 0 0 0 8 8 0 0 0 0 0 8 0 0 0 % Q
% Arg: 8 0 0 54 0 8 0 0 0 0 0 8 0 0 0 % R
% Ser: 0 0 24 8 8 0 47 8 8 16 8 8 0 0 8 % S
% Thr: 0 0 24 0 0 0 0 0 0 0 8 62 8 0 8 % T
% Val: 0 0 0 8 8 8 0 0 0 0 39 0 0 24 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 39 16 8 0 0 0 8 77 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _