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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HEXA All Species: 26.06
Human Site: T303 Identified Species: 47.78
UniProt: P06865 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P06865 NP_000511.2 529 60689 T303 N T Y E F M S T F F L E V S S
Chimpanzee Pan troglodytes XP_001175122 529 60636 T303 N T Y E F M S T F F L E V S S
Rhesus Macaque Macaca mulatta XP_001092589 529 60742 T303 N T Y E F M S T F F L E I S S
Dog Lupus familis XP_544758 529 60532 S303 S T Y E F M S S F F L E V S S
Cat Felis silvestris
Mouse Mus musculus P29416 528 60581 T303 S T Y D F M S T L F L E I S S
Rat Rattus norvegicus Q641X3 528 60520 T303 S T Y D F M S T F F L E I S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513475 574 64498 D351 T T Y N F M S D F F K E V S R
Chicken Gallus gallus NP_001025561 526 58930 S302 T T Y Q F V T S L F Q E I S S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001017763 532 60708 R308 T T Y R F M E R L L K E V K F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q8WSF3 660 75468 N412 G Q L N P K N N Y T Y L I L Q
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q22492 555 64361 E305 A N F D F I S E F L E E V T E
Sea Urchin Strong. purpuratus XP_799340 543 61806 I321 A N Y D F L K I F F K E V V D
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001142218 433 49746 N237 D F T C W K S N P N I Q A F M
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 97.7 81.8 N.A. 84.1 82.8 N.A. 54.5 66.1 N.A. 55.2 N.A. 27.7 N.A. 38.3 49.3
Protein Similarity: 100 99.8 99.2 90.7 N.A. 91.1 90.3 N.A. 66.7 78 N.A. 69.9 N.A. 41.6 N.A. 54.2 64.4
P-Site Identity: 100 100 93.3 86.6 N.A. 73.3 80 N.A. 66.6 46.6 N.A. 40 N.A. 0 N.A. 33.3 40
P-Site Similarity: 100 100 100 100 N.A. 93.3 100 N.A. 66.6 80 N.A. 40 N.A. 20 N.A. 60 53.3
Percent
Protein Identity: N.A. 70.7 N.A. N.A. N.A. N.A.
Protein Similarity: N.A. 77.3 N.A. N.A. N.A. N.A.
P-Site Identity: N.A. 6.6 N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. 33.3 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % A
% Cys: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 31 0 0 0 8 0 0 0 0 0 0 8 % D
% Glu: 0 0 0 31 0 0 8 8 0 0 8 85 0 0 8 % E
% Phe: 0 8 8 0 85 0 0 0 62 70 0 0 0 8 8 % F
% Gly: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 8 0 8 0 0 8 0 39 0 0 % I
% Lys: 0 0 0 0 0 16 8 0 0 0 24 0 0 8 0 % K
% Leu: 0 0 8 0 0 8 0 0 24 16 47 8 0 8 0 % L
% Met: 0 0 0 0 0 62 0 0 0 0 0 0 0 0 8 % M
% Asn: 24 16 0 16 0 0 8 16 0 8 0 0 0 0 0 % N
% Pro: 0 0 0 0 8 0 0 0 8 0 0 0 0 0 0 % P
% Gln: 0 8 0 8 0 0 0 0 0 0 8 8 0 0 8 % Q
% Arg: 0 0 0 8 0 0 0 8 0 0 0 0 0 0 8 % R
% Ser: 24 0 0 0 0 0 70 16 0 0 0 0 0 62 54 % S
% Thr: 24 70 8 0 0 0 8 39 0 8 0 0 0 8 0 % T
% Val: 0 0 0 0 0 8 0 0 0 0 0 0 54 8 0 % V
% Trp: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 77 0 0 0 0 0 8 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _