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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2S1
All Species:
11.52
Human Site:
S161
Identified Species:
28.15
UniProt:
P05198
Number Species:
9
Phosphosite Substitution
Charge Score:
0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P05198
NP_004085.1
315
36112
S161
K
H
A
V
S
D
P
S
I
L
D
S
L
D
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
P68101
315
36090
S161
K
H
A
V
S
D
P
S
I
L
D
S
L
D
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505360
315
36118
S161
K
H
A
V
S
D
P
S
I
L
D
G
L
D
L
Chicken
Gallus gallus
Q5ZLX2
315
36160
A161
K
H
A
V
S
D
P
A
I
L
D
S
L
D
L
Frog
Xenopus laevis
Q7ZTK4
315
36026
D161
K
N
A
V
S
D
P
D
I
L
D
G
L
D
L
Zebra Danio
Brachydanio rerio
NP_571875
315
36121
A161
K
Q
A
V
S
D
P
A
I
L
D
G
L
D
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P41374
341
38627
V160
Q
S
V
T
D
P
T
V
F
D
E
C
N
L
E
Honey Bee
Apis mellifera
XP_001122232
303
33959
S160
K
Q
S
V
L
D
P
S
I
L
A
E
V
A
C
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_779939
313
35603
E160
K
T
C
V
N
E
P
E
L
L
A
E
C
N
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P20459
304
34699
P161
V
W
E
G
I
E
P
P
S
K
D
V
L
D
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
N.A.
N.A.
N.A.
99
N.A.
97.7
97.1
92.6
94.2
N.A.
58
44.7
N.A.
69.5
Protein Similarity:
100
N.A.
N.A.
N.A.
N.A.
N.A.
99.6
N.A.
98.7
98.7
98.7
97.1
N.A.
71.8
60
N.A.
81.2
P-Site Identity:
100
N.A.
N.A.
N.A.
N.A.
N.A.
100
N.A.
93.3
93.3
80
80
N.A.
0
46.6
N.A.
33.3
P-Site Similarity:
100
N.A.
N.A.
N.A.
N.A.
N.A.
100
N.A.
93.3
100
86.6
86.6
N.A.
13.3
60
N.A.
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
52.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
73
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
60
0
0
0
0
20
0
0
20
0
0
10
0
% A
% Cys:
0
0
10
0
0
0
0
0
0
0
0
10
10
0
10
% C
% Asp:
0
0
0
0
10
70
0
10
0
10
70
0
0
70
0
% D
% Glu:
0
0
10
0
0
20
0
10
0
0
10
20
0
0
20
% E
% Phe:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% F
% Gly:
0
0
0
10
0
0
0
0
0
0
0
30
0
0
0
% G
% His:
0
40
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
10
0
0
0
70
0
0
0
0
0
0
% I
% Lys:
80
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% K
% Leu:
0
0
0
0
10
0
0
0
10
80
0
0
70
10
70
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
0
10
0
0
0
0
0
0
0
10
10
0
% N
% Pro:
0
0
0
0
0
10
90
10
0
0
0
0
0
0
0
% P
% Gln:
10
20
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
10
10
0
60
0
0
40
10
0
0
30
0
0
0
% S
% Thr:
0
10
0
10
0
0
10
0
0
0
0
0
0
0
0
% T
% Val:
10
0
10
80
0
0
0
10
0
0
0
10
10
0
0
% V
% Trp:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _