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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ALPL
All Species:
31.82
Human Site:
Y388
Identified Species:
58.33
UniProt:
P05186
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P05186
NP_000469.3
524
57305
Y388
H
V
F
T
F
G
G
Y
T
P
R
G
N
S
I
Chimpanzee
Pan troglodytes
XP_001142681
961
103936
G818
S
H
V
F
S
F
G
G
Y
T
L
R
G
S
S
Rhesus Macaque
Macaca mulatta
XP_001109717
652
71041
Y516
H
V
F
T
F
G
G
Y
T
P
R
G
N
S
I
Dog
Lupus familis
XP_535374
522
57256
Y385
H
V
F
T
F
G
G
Y
T
P
R
G
N
S
I
Cat
Felis silvestris
Mouse
Mus musculus
P09242
524
57437
Y388
H
V
F
T
F
G
G
Y
T
P
R
G
N
S
I
Rat
Rattus norvegicus
P08289
524
57641
Y388
H
V
F
T
F
G
G
Y
T
P
R
G
N
S
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q92058
519
56742
D377
T
L
S
V
V
T
A
D
H
S
H
V
F
T
F
Frog
Xenopus laevis
NP_001080895
526
57659
Y388
H
V
F
T
F
G
G
Y
T
H
R
G
N
P
I
Zebra Danio
Brachydanio rerio
NP_001014375
532
58340
G394
S
H
V
F
T
F
G
G
K
T
P
R
G
N
P
Tiger Blowfish
Takifugu rubipres
NP_001027823
527
57490
Y391
H
V
F
N
F
G
G
Y
T
H
R
G
N
T
I
Fruit Fly
Dros. melanogaster
Q24238
596
65244
S438
D
I
L
G
T
A
N
S
H
E
K
N
D
P
M
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001130844
524
57641
Y388
H
V
F
T
F
G
G
Y
T
P
R
G
N
S
I
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P11491
566
62986
H418
R
K
L
V
D
F
V
H
E
H
K
G
A
S
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
33.6
78.2
87.9
N.A.
89.8
90.8
N.A.
N.A.
74.8
72
57.8
71.9
38.5
N.A.
N.A.
N.A.
Protein Similarity:
100
41.9
79.4
93.6
N.A.
94.4
95
N.A.
N.A.
83.7
84
69.9
81.4
53
N.A.
N.A.
N.A.
P-Site Identity:
100
13.3
100
100
N.A.
100
100
N.A.
N.A.
0
86.6
6.6
80
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
N.A.
13.3
86.6
13.3
86.6
26.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
90.8
N.A.
N.A.
26.3
N.A.
Protein Similarity:
N.A.
95
N.A.
N.A.
43.6
N.A.
P-Site Identity:
N.A.
100
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
100
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
8
0
0
0
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
8
0
0
8
0
0
0
0
8
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
8
8
0
0
0
0
0
% E
% Phe:
0
0
62
16
62
24
0
0
0
0
0
0
8
0
8
% F
% Gly:
0
0
0
8
0
62
77
16
0
0
0
70
16
0
0
% G
% His:
62
16
0
0
0
0
0
8
16
24
8
0
0
0
0
% H
% Ile:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
62
% I
% Lys:
0
8
0
0
0
0
0
0
8
0
16
0
0
0
0
% K
% Leu:
0
8
16
0
0
0
0
0
0
0
8
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
8
0
0
8
0
0
0
0
8
62
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
47
8
0
0
16
8
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
8
0
0
0
0
0
0
0
0
0
62
16
0
0
0
% R
% Ser:
16
0
8
0
8
0
0
8
0
8
0
0
0
62
16
% S
% Thr:
8
0
0
54
16
8
0
0
62
16
0
0
0
16
0
% T
% Val:
0
62
16
16
8
0
8
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
62
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _