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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ALPL
All Species:
19.39
Human Site:
S17
Identified Species:
35.56
UniProt:
P05186
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P05186
NP_000469.3
524
57305
S17
I
G
T
C
L
T
N
S
L
V
P
E
K
E
K
Chimpanzee
Pan troglodytes
XP_001142681
961
103936
G19
L
R
L
Q
L
S
L
G
I
I
P
V
E
E
E
Rhesus Macaque
Macaca mulatta
XP_001109717
652
71041
S145
I
G
T
C
L
T
N
S
L
V
P
E
K
E
K
Dog
Lupus familis
XP_535374
522
57256
E18
N
C
L
S
V
Y
T
E
K
E
K
D
P
K
Y
Cat
Felis silvestris
Mouse
Mus musculus
P09242
524
57437
S17
I
G
T
C
L
T
N
S
F
V
P
E
K
E
R
Rat
Rattus norvegicus
P08289
524
57641
S17
I
G
T
C
L
T
N
S
F
V
P
E
K
E
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q92058
519
56742
L17
A
Q
L
C
S
A
S
L
V
P
E
R
E
K
D
Frog
Xenopus laevis
NP_001080895
526
57659
V17
L
G
T
L
S
E
S
V
T
F
P
E
Q
E
K
Zebra Danio
Brachydanio rerio
NP_001014375
532
58340
D28
L
N
T
S
C
S
L
D
S
A
A
E
W
E
K
Tiger Blowfish
Takifugu rubipres
NP_001027823
527
57490
P21
I
L
G
S
L
G
K
P
S
F
P
E
Q
E
K
Fruit Fly
Dros. melanogaster
Q24238
596
65244
K49
Q
F
D
V
G
K
T
K
E
P
E
D
A
E
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001130844
524
57641
S17
I
G
T
C
L
T
N
S
F
V
P
E
K
E
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P11491
566
62986
S20
L
V
P
G
S
D
S
S
S
R
P
K
K
R
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
33.6
78.2
87.9
N.A.
89.8
90.8
N.A.
N.A.
74.8
72
57.8
71.9
38.5
N.A.
N.A.
N.A.
Protein Similarity:
100
41.9
79.4
93.6
N.A.
94.4
95
N.A.
N.A.
83.7
84
69.9
81.4
53
N.A.
N.A.
N.A.
P-Site Identity:
100
20
100
0
N.A.
86.6
93.3
N.A.
N.A.
6.6
40
26.6
40
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
60
100
20
N.A.
93.3
93.3
N.A.
N.A.
33.3
60
40
46.6
13.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
90.8
N.A.
N.A.
26.3
N.A.
Protein Similarity:
N.A.
95
N.A.
N.A.
43.6
N.A.
P-Site Identity:
N.A.
93.3
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
93.3
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
8
0
0
0
8
8
0
8
0
0
% A
% Cys:
0
8
0
47
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
8
0
8
0
0
0
16
0
0
8
% D
% Glu:
0
0
0
0
0
8
0
8
8
8
16
62
16
77
8
% E
% Phe:
0
8
0
0
0
0
0
0
24
16
0
0
0
0
8
% F
% Gly:
0
47
8
8
8
8
0
8
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
47
0
0
0
0
0
0
0
8
8
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
8
8
8
8
0
8
8
47
16
54
% K
% Leu:
31
8
24
8
54
0
16
8
16
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
8
0
0
0
0
39
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
8
0
0
0
0
8
0
16
70
0
8
0
0
% P
% Gln:
8
8
0
8
0
0
0
0
0
0
0
0
16
0
0
% Q
% Arg:
0
8
0
0
0
0
0
0
0
8
0
8
0
8
16
% R
% Ser:
0
0
0
24
24
16
24
47
24
0
0
0
0
0
0
% S
% Thr:
0
0
54
0
0
39
16
0
8
0
0
0
0
0
0
% T
% Val:
0
8
0
8
8
0
0
8
8
39
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _