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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: All Species: 5.76
Human Site: S257 Identified Species: 18.1
UniProt: P04220 Number Species: 7
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P04220 XP_002348298 391 43057 S257 S P L K Q T I S R P K G V A L
Chimpanzee Pan troglodytes XP_522970 288 32022 E156 A K T K P R E E Q Y N S T F R
Rhesus Macaque Macaca mulatta XP_001116723 398 43362 R263 S P E D V L V R W L K G T E Q
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P01872 454 49953 S320 S P Q K K F I S K P N E V H K
Rat Rattus norvegicus P20759 326 35927 N194 I L H Q D W L N G R T F R C K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507959 649 72041 T465 S P I I K T V T K L P G K R L
Chicken Gallus gallus P01875 446 48155 R312 F P M E E K M R K T K A S N A
Frog Xenopus laevis NP_001079873 614 68235 L454 A S M K E V F L F K E K G E Y
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 24.8 30.1 N.A. N.A. 55.9 27.6 N.A. 23.2 28.2 24.7 N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 39.6 44.9 N.A. N.A. 66.3 41.1 N.A. 36.8 46.8 43.3 N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 6.6 26.6 N.A. N.A. 46.6 0 N.A. 33.3 13.3 6.6 N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 20 33.3 N.A. N.A. 60 20 N.A. 66.6 46.6 33.3 N.A. N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 25 0 0 0 0 0 0 0 0 0 0 13 0 13 13 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 13 0 % C
% Asp: 0 0 0 13 13 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 13 13 25 0 13 13 0 0 13 13 0 25 0 % E
% Phe: 13 0 0 0 0 13 13 0 13 0 0 13 0 13 0 % F
% Gly: 0 0 0 0 0 0 0 0 13 0 0 38 13 0 0 % G
% His: 0 0 13 0 0 0 0 0 0 0 0 0 0 13 0 % H
% Ile: 13 0 13 13 0 0 25 0 0 0 0 0 0 0 0 % I
% Lys: 0 13 0 50 25 13 0 0 38 13 38 13 13 0 25 % K
% Leu: 0 13 13 0 0 13 13 13 0 25 0 0 0 0 25 % L
% Met: 0 0 25 0 0 0 13 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 13 0 0 25 0 0 13 0 % N
% Pro: 0 63 0 0 13 0 0 0 0 25 13 0 0 0 0 % P
% Gln: 0 0 13 13 13 0 0 0 13 0 0 0 0 0 13 % Q
% Arg: 0 0 0 0 0 13 0 25 13 13 0 0 13 13 13 % R
% Ser: 50 13 0 0 0 0 0 25 0 0 0 13 13 0 0 % S
% Thr: 0 0 13 0 0 25 0 13 0 13 13 0 25 0 0 % T
% Val: 0 0 0 0 13 13 25 0 0 0 0 0 25 0 0 % V
% Trp: 0 0 0 0 0 13 0 0 13 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 13 0 0 0 0 13 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _