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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LCAT
All Species:
7.58
Human Site:
T431
Identified Species:
18.52
UniProt:
P04180
Number Species:
9
Phosphosite Substitution
Charge Score:
0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04180
NP_000220.1
440
49578
T431
Q
G
P
P
A
S
P
T
A
S
P
E
P
P
P
Chimpanzee
Pan troglodytes
XP_001166428
404
45611
T395
Q
G
P
P
A
S
P
T
A
S
P
E
P
P
P
Rhesus Macaque
Macaca mulatta
XP_001090154
333
37244
A325
G
P
P
A
S
L
T
A
S
P
E
P
P
P
P
Dog
Lupus familis
XP_851673
438
49717
A429
H
N
T
P
V
P
P
A
A
S
P
G
P
L
P
Cat
Felis silvestris
Mouse
Mus musculus
P16301
438
49746
A429
Y
R
T
P
K
S
P
A
A
S
P
S
P
P
P
Rat
Rattus norvegicus
P18424
440
49708
T431
H
G
T
P
K
S
P
T
A
S
L
G
P
P
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P53760
413
47786
F404
I
D
H
L
N
M
V
F
S
N
L
T
L
T
L
Frog
Xenopus laevis
NP_001087677
426
48767
D418
Q
T
L
T
L
I
N
D
I
L
L
E
S
N
L
Zebra Danio
Brachydanio rerio
XP_001332828
436
50456
E428
E
E
K
D
V
G
F
E
Q
P
S
S
I
G
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624472
390
44756
N382
L
K
N
N
N
V
L
N
Y
I
R
T
L
L
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
89.3
71.3
92.9
N.A.
85.6
86.3
N.A.
N.A.
67.5
62.9
58.4
N.A.
N.A.
34.5
N.A.
N.A.
Protein Similarity:
100
89.7
72.2
94.7
N.A.
90.9
92
N.A.
N.A.
78.1
76.3
76.1
N.A.
N.A.
51.5
N.A.
N.A.
P-Site Identity:
100
100
26.6
46.6
N.A.
60
66.6
N.A.
N.A.
0
13.3
0
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
100
100
40
46.6
N.A.
60
66.6
N.A.
N.A.
13.3
13.3
6.6
N.A.
N.A.
0
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
20
0
0
30
50
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
10
0
0
0
10
0
0
0
0
0
0
0
% D
% Glu:
10
10
0
0
0
0
0
10
0
0
10
30
0
0
0
% E
% Phe:
0
0
0
0
0
0
10
10
0
0
0
0
0
0
10
% F
% Gly:
10
30
0
0
0
10
0
0
0
0
0
20
0
10
0
% G
% His:
20
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
0
0
0
0
10
0
0
10
10
0
0
10
0
0
% I
% Lys:
0
10
10
0
20
0
0
0
0
0
0
0
0
0
10
% K
% Leu:
10
0
10
10
10
10
10
0
0
10
30
0
20
20
20
% L
% Met:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
10
10
20
0
10
10
0
10
0
0
0
10
0
% N
% Pro:
0
10
30
50
0
10
50
0
0
20
40
10
60
50
60
% P
% Gln:
30
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% Q
% Arg:
0
10
0
0
0
0
0
0
0
0
10
0
0
0
0
% R
% Ser:
0
0
0
0
10
40
0
0
20
50
10
20
10
0
0
% S
% Thr:
0
10
30
10
0
0
10
30
0
0
0
20
0
10
0
% T
% Val:
0
0
0
0
20
10
10
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _