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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRNP
All Species:
17.27
Human Site:
S222
Identified Species:
54.29
UniProt:
P04156
Number Species:
7
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04156
NP_000302.1
253
27661
S222
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
Chimpanzee
Pan troglodytes
NP_001009093
253
27615
S222
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
Rhesus Macaque
Macaca mulatta
NP_001040617
253
27658
S222
I
T
Q
Y
E
K
E
S
Q
A
Y
Y
Q
R
G
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P04925
254
27959
S221
V
T
Q
Y
Q
K
E
S
Q
A
Y
Y
D
G
R
Rat
Rattus norvegicus
P13852
254
27786
S222
V
T
Q
Y
Q
K
E
S
Q
A
Y
Y
D
G
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516688
183
19570
T153
V
R
D
C
V
N
I
T
V
T
Q
H
T
V
T
Chicken
Gallus gallus
NP_990796
267
29294
E229
V
V
T
K
V
I
R
E
M
C
V
Q
Q
Y
R
Frog
Xenopus laevis
NP_001082180
216
24339
C185
S
Q
I
I
R
E
M
C
I
T
E
Y
R
R
G
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
96.4
N.A.
N.A.
89.3
89.3
N.A.
47
36.7
33.2
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
100
100
N.A.
N.A.
95.2
95.6
N.A.
56.1
47.5
50.2
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
N.A.
N.A.
60
60
N.A.
0
6.6
20
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
N.A.
N.A.
80
80
N.A.
20
13.3
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
63
0
0
0
0
0
% A
% Cys:
0
0
0
13
0
0
0
13
0
13
0
0
0
0
0
% C
% Asp:
0
0
13
0
0
0
0
0
0
0
0
0
25
0
0
% D
% Glu:
0
0
0
0
38
13
63
13
0
0
13
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
25
50
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
13
0
0
0
% H
% Ile:
38
0
13
13
0
13
13
0
13
0
0
0
0
0
0
% I
% Lys:
0
0
0
13
0
38
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
13
0
13
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
13
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
13
63
0
25
0
0
0
63
0
13
13
50
0
0
% Q
% Arg:
0
13
0
0
13
25
13
0
0
0
0
0
13
50
38
% R
% Ser:
13
0
0
0
0
0
0
63
0
0
0
0
0
0
0
% S
% Thr:
0
63
13
0
0
0
0
13
0
25
0
0
13
0
13
% T
% Val:
50
13
0
0
25
0
0
0
13
0
13
0
0
13
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
63
0
0
0
0
0
0
63
75
0
13
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _