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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CAT All Species: 25.45
Human Site: Y500 Identified Species: 62.22
UniProt: P04040 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P04040 NP_001743.1 527 59756 Y500 I Q A L L D K Y N A E K P K N
Chimpanzee Pan troglodytes XP_001147928 527 59674 Y500 I Q A L L D K Y N A E K P K N
Rhesus Macaque Macaca mulatta XP_001115625 527 59924 Y500 I Q T L L D K Y N A E K P K N
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P24270 527 59747 Y500 I Q A L L D K Y N A E K P K N
Rat Rattus norvegicus P04762 527 59739 Y500 V Q A L L D Q Y N S Q K P K N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507740 575 65276 Y548 I Q A L L D K Y N A M E K K N
Chicken Gallus gallus
Frog Xenopus laevis NP_001080544 528 60240 Y500 I Q A L L D K Y N A E G A K K
Zebra Danio Brachydanio rerio Q9PT92 526 59636 H500 V Q A L L D K H N A E G K K N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P17336 506 57131 N482 L Q E R A V K N F T Q V H A D
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q27487 500 57448 H476 I I K G M I D H F S K V H P D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 97.5 N.A. N.A. 89.5 88.9 N.A. 77.3 N.A. 80.8 76.8 N.A. 63.9 N.A. 60.5 N.A.
Protein Similarity: 100 99.4 98.4 N.A. N.A. 95.2 94.8 N.A. 84.1 N.A. 88.8 86.9 N.A. 77.2 N.A. 75.9 N.A.
P-Site Identity: 100 100 93.3 N.A. N.A. 100 73.3 N.A. 80 N.A. 80 73.3 N.A. 13.3 N.A. 6.6 N.A.
P-Site Similarity: 100 100 93.3 N.A. N.A. 100 100 N.A. 86.6 N.A. 80 86.6 N.A. 33.3 N.A. 40 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 70 0 10 0 0 0 0 70 0 0 10 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 80 10 0 0 0 0 0 0 0 20 % D
% Glu: 0 0 10 0 0 0 0 0 0 0 60 10 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 20 0 0 0 0 0 0 % F
% Gly: 0 0 0 10 0 0 0 0 0 0 0 20 0 0 0 % G
% His: 0 0 0 0 0 0 0 20 0 0 0 0 20 0 0 % H
% Ile: 70 10 0 0 0 10 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 10 0 0 0 80 0 0 0 10 50 20 80 10 % K
% Leu: 10 0 0 80 80 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 10 0 0 0 0 0 10 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 10 80 0 0 0 0 0 70 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 50 10 0 % P
% Gln: 0 90 0 0 0 0 10 0 0 0 20 0 0 0 0 % Q
% Arg: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 0 0 20 0 0 0 0 0 % S
% Thr: 0 0 10 0 0 0 0 0 0 10 0 0 0 0 0 % T
% Val: 20 0 0 0 0 10 0 0 0 0 0 20 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 70 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _