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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: APCS All Species: 20
Human Site: S166 Identified Species: 48.89
UniProt: P02743 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P02743 NP_001630.1 223 25387 S166 Y G G K F D R S Q S F V G E I
Chimpanzee Pan troglodytes XP_513916 223 25403 S166 Y G G K F D R S Q S F V G E I
Rhesus Macaque Macaca mulatta XP_001117234 223 25296 S166 Y G G K F D K S Q S F V G E I
Dog Lupus familis XP_545746 318 35124 N261 F G G G F D K N Q S L V G D I
Cat Felis silvestris
Mouse Mus musculus P12246 224 26228 S167 Y G G G F Q R S Q S F V G E F
Rat Rattus norvegicus P23680 228 26157 T167 Y G G G F D K T Q S F V G E I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521709 287 31507 G218 G Y K V G A G G Q M I L G Q E
Chicken Gallus gallus NP_001034653 227 25642 Y166 Y G G G F D V Y N S F T G E M
Frog Xenopus laevis Q07203 238 27066 D165 F G G G F N I D Q S F V G E I
Zebra Danio Brachydanio rerio NP_001020468 222 24929 A165 Y V G S F N A A Q S F V G E I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.2 90.5 34.2 N.A. 68.7 70.1 N.A. 41.4 45.8 36.1 37.2 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99 95 48.1 N.A. 81.2 82 N.A. 54 63.4 54.2 56 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 93.3 60 N.A. 80 80 N.A. 13.3 60 66.6 66.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 86.6 N.A. 80 93.3 N.A. 26.6 66.6 80 80 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 10 10 10 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 60 0 10 0 0 0 0 0 10 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 80 10 % E
% Phe: 20 0 0 0 90 0 0 0 0 0 80 0 0 0 10 % F
% Gly: 10 80 90 50 10 0 10 10 0 0 0 0 100 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 10 0 0 0 10 0 0 0 70 % I
% Lys: 0 0 10 30 0 0 30 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 10 10 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 10 % M
% Asn: 0 0 0 0 0 20 0 10 10 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 10 0 0 90 0 0 0 0 10 0 % Q
% Arg: 0 0 0 0 0 0 30 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 10 0 0 0 40 0 90 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 10 0 0 0 10 0 0 0 % T
% Val: 0 10 0 10 0 0 10 0 0 0 0 80 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 70 10 0 0 0 0 0 10 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _