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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: F2 All Species: 5.15
Human Site: Y320 Identified Species: 9.44
UniProt: P00734 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.33
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P00734 NP_000497.1 622 70037 Y320 G R T A T S E Y Q T F F N P R
Chimpanzee Pan troglodytes Q95ND7 461 51746 R180 A V P F P C G R V S V S Q T S
Rhesus Macaque Macaca mulatta NP_001098055 627 70600 Y325 G R T A T S E Y Q T F F D P R
Dog Lupus familis XP_855946 493 54567 S212 Q Y D P G D L S P T Q S T M F
Cat Felis silvestris
Mouse Mus musculus P19221 618 70250 F317 G R T T D A E F H T F F N E K
Rat Rattus norvegicus P18292 617 70393 F316 G R T T D A E F H T F F D E R
Wallaby Macropus eugenll O18783 806 90963 R380 E G K G E N Y R G T T S T T I
Platypus Ornith. anatinus XP_001511876 701 76014 T401 V A F P G F G T S G P A F P A
Chicken Gallus gallus P25155 475 53123 N194 V I L P T N S N T N A T S D Q
Frog Xenopus laevis NP_001086517 607 69214 H305 G R T T A E E H Q I F F D E K
Zebra Danio Brachydanio rerio NP_998555 524 59542 K243 G E R P L F E K I N K A D K N
Tiger Blowfish Takifugu rubipres NP_001027864 612 69604 K314 R T T L S S S K K R F F N P R
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783851 948 105521 G663 D Q R G N Q R G E A Y A W L T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 28.4 92.6 32.9 N.A. 81.1 79.9 23.3 44.3 31.1 58.6 50.3 52.8 N.A. N.A. N.A. 24.4
Protein Similarity: 100 43.8 95 45.3 N.A. 88.7 88 37.1 54.2 46.7 74.4 64.4 70.7 N.A. N.A. N.A. 37.2
P-Site Identity: 100 0 93.3 6.6 N.A. 53.3 53.3 6.6 6.6 6.6 46.6 13.3 46.6 N.A. N.A. N.A. 0
P-Site Similarity: 100 6.6 100 6.6 N.A. 73.3 73.3 13.3 6.6 26.6 66.6 20 60 N.A. N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 0 16 8 16 0 0 0 8 8 24 0 0 8 % A
% Cys: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 8 0 16 8 0 0 0 0 0 0 31 8 0 % D
% Glu: 8 8 0 0 8 8 47 0 8 0 0 0 0 24 0 % E
% Phe: 0 0 8 8 0 16 0 16 0 0 47 47 8 0 8 % F
% Gly: 47 8 0 16 16 0 16 8 8 8 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 8 16 0 0 0 0 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 8 8 0 0 0 0 8 % I
% Lys: 0 0 8 0 0 0 0 16 8 0 8 0 0 8 16 % K
% Leu: 0 0 8 8 8 0 8 0 0 0 0 0 0 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % M
% Asn: 0 0 0 0 8 16 0 8 0 16 0 0 24 0 8 % N
% Pro: 0 0 8 31 8 0 0 0 8 0 8 0 0 31 0 % P
% Gln: 8 8 0 0 0 8 0 0 24 0 8 0 8 0 8 % Q
% Arg: 8 39 16 0 0 0 8 16 0 8 0 0 0 0 31 % R
% Ser: 0 0 0 0 8 24 16 8 8 8 0 24 8 0 8 % S
% Thr: 0 8 47 24 24 0 0 8 8 47 8 8 16 16 8 % T
% Val: 16 8 0 0 0 0 0 0 8 0 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % W
% Tyr: 0 8 0 0 0 0 8 16 0 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _