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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: F2 All Species: 18.79
Human Site: T512 Identified Species: 34.44
UniProt: P00734 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P00734 NP_000497.1 622 70037 T512 G N L K E T W T A N V G K G Q
Chimpanzee Pan troglodytes Q95ND7 461 51746 S365 R V F H K G R S A L V L Q Y L
Rhesus Macaque Macaca mulatta NP_001098055 627 70600 T517 G N L K E T W T T N V G K V Q
Dog Lupus familis XP_855946 493 54567 V397 K M M E V P Y V D R N T C K L
Cat Felis silvestris
Mouse Mus musculus P19221 618 70250 T509 G N L R E T W T T N I N E I Q
Rat Rattus norvegicus P18292 617 70393 T508 G N L R E T W T T N I N E I Q
Wallaby Macropus eugenll O18783 806 90963 S651 Y S Q E I G V S R L F K G P L
Platypus Ornith. anatinus XP_001511876 701 76014 T593 G N L K E T W T T T R N L P S
Chicken Gallus gallus P25155 475 53123 L379 R E F E A G R L S K R L K V L
Frog Xenopus laevis NP_001086517 607 69214 S497 G N L Q E T W S A G A Q N L P
Zebra Danio Brachydanio rerio NP_998555 524 59542 I428 L Q Q I H L P I V D Q S I C R
Tiger Blowfish Takifugu rubipres NP_001027864 612 69604 D506 G N L K E S F D P A A R N L P
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783851 948 105521 P850 G Q I A E G G P Y P R Y L T E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 28.4 92.6 32.9 N.A. 81.1 79.9 23.3 44.3 31.1 58.6 50.3 52.8 N.A. N.A. N.A. 24.4
Protein Similarity: 100 43.8 95 45.3 N.A. 88.7 88 37.1 54.2 46.7 74.4 64.4 70.7 N.A. N.A. N.A. 37.2
P-Site Identity: 100 13.3 86.6 0 N.A. 60 60 0 53.3 6.6 46.6 0 33.3 N.A. N.A. N.A. 13.3
P-Site Similarity: 100 33.3 86.6 20 N.A. 80 80 20 53.3 20 60 13.3 46.6 N.A. N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 8 0 0 0 24 8 16 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 8 8 0 % C
% Asp: 0 0 0 0 0 0 0 8 8 8 0 0 0 0 0 % D
% Glu: 0 8 0 24 62 0 0 0 0 0 0 0 16 0 8 % E
% Phe: 0 0 16 0 0 0 8 0 0 0 8 0 0 0 0 % F
% Gly: 62 0 0 0 0 31 8 0 0 8 0 16 8 8 0 % G
% His: 0 0 0 8 8 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 8 8 8 0 0 8 0 0 16 0 8 16 0 % I
% Lys: 8 0 0 31 8 0 0 0 0 8 0 8 24 8 0 % K
% Leu: 8 0 54 0 0 8 0 8 0 16 0 16 16 16 31 % L
% Met: 0 8 8 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 54 0 0 0 0 0 0 0 31 8 24 16 0 0 % N
% Pro: 0 0 0 0 0 8 8 8 8 8 0 0 0 16 16 % P
% Gln: 0 16 16 8 0 0 0 0 0 0 8 8 8 0 31 % Q
% Arg: 16 0 0 16 0 0 16 0 8 8 24 8 0 0 8 % R
% Ser: 0 8 0 0 0 8 0 24 8 0 0 8 0 0 8 % S
% Thr: 0 0 0 0 0 47 0 39 31 8 0 8 0 8 0 % T
% Val: 0 8 0 0 8 0 8 8 8 0 24 0 0 16 0 % V
% Trp: 0 0 0 0 0 0 47 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 8 0 8 0 0 8 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _