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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HPRT1
All Species:
36.36
Human Site:
Y198
Identified Species:
80
UniProt:
P00492
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P00492
NP_000185.1
218
24579
Y198
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
Chimpanzee
Pan troglodytes
A5A6I1
218
24549
Y198
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
Rhesus Macaque
Macaca mulatta
XP_001097691
250
28479
Y230
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
Dog
Lupus familis
XP_544231
256
29310
Y236
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
I
Cat
Felis silvestris
Mouse
Mus musculus
P00493
218
24552
Y198
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
V
Rat
Rattus norvegicus
P27605
218
24459
H198
Y
A
L
D
Y
N
E
H
F
R
D
L
N
H
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514524
218
24506
Y198
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
I
Chicken
Gallus gallus
Q9W719
218
24590
Y198
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
I
Frog
Xenopus laevis
Q6DCP3
224
25856
Y204
Y
A
L
D
Y
N
E
Y
F
R
D
L
H
H
I
Zebra Danio
Brachydanio rerio
NP_998151
218
24680
Y198
Y
A
L
D
Y
N
E
Y
F
R
D
L
N
H
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_493545
214
23806
K193
Y
G
L
D
Y
N
Q
K
F
R
D
L
G
H
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
86.4
55.8
N.A.
96.7
95.4
N.A.
93.5
90.8
62.9
91.2
N.A.
N.A.
N.A.
49.5
N.A.
Protein Similarity:
100
99.5
86.4
71
N.A.
98.6
98.6
N.A.
96.7
96.7
80.8
96.3
N.A.
N.A.
N.A.
62.8
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
100
93.3
N.A.
93.3
93.3
86.6
93.3
N.A.
N.A.
N.A.
66.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
N.A.
N.A.
80
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
91
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
100
0
0
0
0
0
0
100
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
91
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
100
0
0
0
0
0
0
% F
% Gly:
0
10
0
0
0
0
0
0
0
0
0
0
10
0
0
% G
% His:
0
0
0
0
0
0
0
10
0
0
0
0
10
100
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
55
% I
% Lys:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% K
% Leu:
0
0
100
0
0
0
0
0
0
0
0
100
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
100
0
0
0
0
0
0
82
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
100
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
46
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
100
0
0
0
100
0
0
82
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _