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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
OTC
All Species:
22.73
Human Site:
S346
Identified Species:
45.45
UniProt:
P00480
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P00480
NP_000522.3
354
39935
S346
V
S
L
L
T
D
Y
S
P
Q
L
Q
K
P
K
Chimpanzee
Pan troglodytes
XP_001139972
223
25139
P216
S
L
L
T
D
Y
S
P
Q
L
Q
K
P
K
F
Rhesus Macaque
Macaca mulatta
XP_001086929
254
28283
P247
S
L
L
T
D
Y
S
P
Q
L
Q
K
P
K
F
Dog
Lupus familis
XP_537995
354
39887
S346
V
S
L
L
T
D
Y
S
P
Q
L
Q
K
P
K
Cat
Felis silvestris
Mouse
Mus musculus
P11725
354
39746
S346
V
S
L
L
T
D
Y
S
P
V
L
Q
K
P
K
Rat
Rattus norvegicus
P00481
354
39868
S346
V
S
L
L
T
D
Y
S
P
V
L
Q
K
P
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513452
362
40782
S354
V
S
L
L
T
D
Y
S
P
Q
L
P
K
P
T
Chicken
Gallus gallus
Q9YHY9
354
40227
S346
V
S
L
L
T
D
Y
S
P
Q
L
Q
M
P
T
Frog
Xenopus laevis
NP_001079087
351
39217
I343
V
A
L
L
T
D
Y
I
P
Q
L
P
K
P
T
Zebra Danio
Brachydanio rerio
XP_001334671
352
39645
R344
V
C
I
L
T
D
Y
R
P
Q
I
P
T
L
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793635
357
39695
T347
A
A
E
N
R
K
W
T
A
M
V
R
K
S
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P05150
338
37827
K331
I
D
I
F
V
N
N
K
G
N
F
K
D
L
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
55.3
71.1
96.8
N.A.
92.6
91.8
N.A.
82.3
75.4
75.1
68.3
N.A.
N.A.
N.A.
N.A.
56.3
Protein Similarity:
100
57
71.1
97.4
N.A.
96
95.1
N.A.
88.6
85.8
85.3
80.2
N.A.
N.A.
N.A.
N.A.
70.3
P-Site Identity:
100
6.6
6.6
100
N.A.
93.3
93.3
N.A.
86.6
86.6
73.3
53.3
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
13.3
13.3
100
N.A.
93.3
93.3
N.A.
86.6
86.6
80
66.6
N.A.
N.A.
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
36.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
58.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
17
0
0
0
0
0
0
9
0
0
0
0
0
0
% A
% Cys:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
0
0
17
67
0
0
0
0
0
0
9
0
0
% D
% Glu:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
9
0
0
0
0
0
0
9
0
0
0
17
% F
% Gly:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
9
0
17
0
0
0
0
9
0
0
9
0
0
0
0
% I
% Lys:
0
0
0
0
0
9
0
9
0
0
0
25
59
17
50
% K
% Leu:
0
17
75
67
0
0
0
0
0
17
59
0
0
17
9
% L
% Met:
0
0
0
0
0
0
0
0
0
9
0
0
9
0
0
% M
% Asn:
0
0
0
9
0
9
9
0
0
9
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
17
67
0
0
25
17
59
0
% P
% Gln:
0
0
0
0
0
0
0
0
17
50
17
42
0
0
0
% Q
% Arg:
0
0
0
0
9
0
0
9
0
0
0
9
0
0
0
% R
% Ser:
17
50
0
0
0
0
17
50
0
0
0
0
0
9
0
% S
% Thr:
0
0
0
17
67
0
0
9
0
0
0
0
9
0
25
% T
% Val:
67
0
0
0
9
0
0
0
0
17
9
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
17
67
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _