KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK2
All Species:
23.33
Human Site:
T225
Identified Species:
36.67
UniProt:
O96017
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O96017
NP_001005735.1
543
60915
T225
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
Chimpanzee
Pan troglodytes
XP_001172779
543
60866
T225
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
Rhesus Macaque
Macaca mulatta
XP_001102484
543
60923
T225
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
Dog
Lupus familis
XP_543464
544
61233
T226
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z265
546
61070
T229
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
Rat
Rattus norvegicus
NP_446129
545
60912
T228
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508699
537
60493
K218
E
V
K
L
A
F
E
K
T
T
C
K
K
V
A
Chicken
Gallus gallus
NP_001073576
522
58779
K222
F
E
K
S
T
C
N
K
V
A
V
K
I
I
N
Frog
Xenopus laevis
NP_001082016
517
58243
K216
A
F
Q
K
S
V
C
K
K
V
A
V
K
I
I
Zebra Danio
Brachydanio rerio
Q501V0
422
47914
C143
E
V
C
E
S
E
L
C
V
L
R
R
V
R
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61267
476
54243
Q198
V
Y
D
T
R
T
C
Q
Q
F
A
M
K
I
V
Honey Bee
Apis mellifera
XP_624334
480
54300
T201
T
I
M
K
L
G
G
T
T
N
G
Q
K
H
P
Nematode Worm
Caenorhab. elegans
Q9U1Y5
476
53320
I198
S
D
R
S
V
V
A
I
K
Q
L
N
T
Q
F
Sea Urchin
Strong. purpuratus
XP_794585
480
52849
I201
R
K
V
A
V
K
I
I
E
K
K
T
F
S
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39009
513
58614
K215
A
G
H
Y
A
L
V
K
E
A
K
N
K
K
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99
89.3
N.A.
83.1
83.4
N.A.
74.4
67.5
59.6
28.1
N.A.
34
37.2
30.2
43.2
Protein Similarity:
100
99.8
99
93
N.A.
89.7
89.9
N.A.
82.1
77.9
73.1
41.9
N.A.
51.5
54.5
49.5
58.3
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
0
6.6
0
0
N.A.
0
6.6
0
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
20
13.3
6.6
13.3
N.A.
13.3
13.3
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
0
0
7
14
0
7
0
0
14
14
0
40
0
7
% A
% Cys:
0
0
7
0
0
7
14
7
0
0
7
0
0
40
0
% C
% Asp:
40
7
7
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
14
47
0
7
0
7
7
0
14
0
0
0
0
0
0
% E
% Phe:
7
7
0
0
0
7
0
0
0
7
0
0
7
0
7
% F
% Gly:
0
7
0
0
0
7
7
0
0
40
7
40
0
0
40
% G
% His:
0
0
7
0
0
0
0
0
0
0
0
0
0
7
7
% H
% Ile:
0
7
0
40
0
0
7
14
0
0
0
0
7
20
14
% I
% Lys:
0
7
14
14
0
7
40
27
14
7
14
14
34
7
0
% K
% Leu:
0
0
0
7
7
7
7
0
40
7
7
0
0
0
0
% L
% Met:
0
0
7
0
40
0
0
0
0
0
0
7
0
0
0
% M
% Asn:
0
0
0
0
0
0
7
0
0
7
0
14
0
0
7
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% P
% Gln:
0
0
7
0
0
0
0
7
7
7
0
7
0
7
0
% Q
% Arg:
7
0
7
0
7
0
0
0
0
0
7
7
0
7
0
% R
% Ser:
7
0
0
14
14
40
0
0
0
0
40
0
0
7
0
% S
% Thr:
7
0
0
7
7
7
0
47
14
7
0
7
7
0
7
% T
% Val:
7
14
7
0
14
14
7
0
14
7
7
7
7
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
40
7
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _