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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: APC2 All Species: 11.21
Human Site: S1587 Identified Species: 22.42
UniProt: O95996 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95996 NP_005874.1 2303 243949 S1587 S S S A S S L S E P E P S E P
Chimpanzee Pan troglodytes XP_001143729 2807 307641 P1966 S Q G E P S K P Q A S G Y A P
Rhesus Macaque Macaca mulatta XP_001095216 2303 243755 S1589 S S S A S S L S E P E P P E P
Dog Lupus familis XP_542202 2539 269675 S1835 S S S A S S L S E P D P P A H
Cat Felis silvestris
Mouse Mus musculus Q9Z1K7 2274 243121 L1557 E T P P C Y S L T S S A S S L
Rat Rattus norvegicus P70478 2842 310514 P2001 A Q G Q P G K P Q A S G Y A P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511806 2844 309621 P2003 T Q I E S S R P Q A S G Y A P
Chicken Gallus gallus
Frog Xenopus laevis P70039 2829 310863 L1994 T G T S E T Q L G L R R P Q T
Zebra Danio Brachydanio rerio XP_694133 2091 233440 M1419 E S E K E E D M E D Q Y S E G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477152 2417 261266 S1556 Q S S T H P S S H I L P N P I
Honey Bee Apis mellifera XP_624558 2760 306907 D1985 P F P D M N Q D Q N N Q Q E I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783363 3212 346162 S1937 S S E E A P L S Y A V E D T P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 35.2 96.4 72.6 N.A. 81.1 34.7 N.A. 35.9 N.A. 34.4 36 N.A. 24.2 22.7 N.A. 25
Protein Similarity: 100 50.4 97.3 76.1 N.A. 85.6 49.8 N.A. 49.9 N.A. 48.7 49.9 N.A. 39 38.1 N.A. 40
P-Site Identity: 100 20 93.3 73.3 N.A. 6.6 6.6 N.A. 20 N.A. 0 26.6 N.A. 26.6 6.6 N.A. 33.3
P-Site Similarity: 100 26.6 93.3 80 N.A. 13.3 20 N.A. 33.3 N.A. 33.3 33.3 N.A. 33.3 20 N.A. 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 0 25 9 0 0 0 0 34 0 9 0 34 0 % A
% Cys: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 9 0 0 9 9 0 9 9 0 9 0 0 % D
% Glu: 17 0 17 25 17 9 0 0 34 0 17 9 0 34 0 % E
% Phe: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 9 17 0 0 9 0 0 9 0 0 25 0 0 9 % G
% His: 0 0 0 0 9 0 0 0 9 0 0 0 0 0 9 % H
% Ile: 0 0 9 0 0 0 0 0 0 9 0 0 0 0 17 % I
% Lys: 0 0 0 9 0 0 17 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 34 17 0 9 9 0 0 0 9 % L
% Met: 0 0 0 0 9 0 0 9 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 9 0 0 0 9 9 0 9 0 0 % N
% Pro: 9 0 17 9 17 17 0 25 0 25 0 34 25 9 50 % P
% Gln: 9 25 0 9 0 0 17 0 34 0 9 9 9 9 0 % Q
% Arg: 0 0 0 0 0 0 9 0 0 0 9 9 0 0 0 % R
% Ser: 42 50 34 9 34 42 17 42 0 9 34 0 25 9 0 % S
% Thr: 17 9 9 9 0 9 0 0 9 0 0 0 0 9 9 % T
% Val: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 9 0 0 9 0 0 9 25 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _