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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP3B
All Species:
40.3
Human Site:
Y411
Identified Species:
73.89
UniProt:
O95985
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95985
NP_003926.1
862
96662
Y411
D
A
W
R
L
Y
E
Y
I
T
R
H
F
I
A
Chimpanzee
Pan troglodytes
XP_515006
956
106787
Y505
D
A
W
R
L
Y
E
Y
I
T
R
H
F
I
A
Rhesus Macaque
Macaca mulatta
XP_001089027
862
96675
Y411
D
A
W
R
L
Y
E
Y
I
T
R
H
F
I
A
Dog
Lupus familis
XP_534771
862
96765
Y411
E
A
W
R
L
Y
E
Y
I
T
R
H
F
I
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z321
862
96931
Y411
D
A
W
R
L
Y
E
Y
I
T
R
H
F
I
A
Rat
Rattus norvegicus
NP_001099331
862
96832
Y411
D
A
W
R
L
Y
E
Y
I
T
R
H
F
I
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001006181
862
96669
Y411
D
S
W
R
L
Y
E
Y
I
T
R
H
F
I
A
Frog
Xenopus laevis
NP_001082554
858
96526
Y411
D
A
W
R
L
Y
E
Y
I
T
R
H
F
I
A
Zebra Danio
Brachydanio rerio
XP_002662012
861
96385
Y411
D
G
W
R
L
Y
D
Y
I
T
R
H
F
I
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O96651
875
96955
F406
D
T
W
R
V
Y
E
F
I
C
R
H
F
M
G
Honey Bee
Apis mellifera
XP_625165
851
95935
Y409
D
T
W
R
L
Y
D
Y
I
T
R
H
F
I
A
Nematode Worm
Caenorhab. elegans
O61660
759
85420
N359
V
Q
Q
Q
T
Q
S
N
I
W
G
D
F
A
N
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13099
656
74352
W258
N
F
V
P
E
E
F
W
Y
I
Q
L
V
V
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90
99.1
95.7
N.A.
95.5
94.6
N.A.
N.A.
87.4
86.1
82.3
N.A.
57.2
64.3
30.5
N.A.
Protein Similarity:
100
90.1
99.7
97.5
N.A.
97.8
97.6
N.A.
N.A.
93.9
93.2
91
N.A.
70
78.3
46.7
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
100
100
N.A.
N.A.
93.3
100
86.6
N.A.
60
86.6
13.3
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
100
93.3
N.A.
80
93.3
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
35.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
54
0
0
0
0
0
0
0
0
0
0
0
8
77
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
77
0
0
0
0
0
16
0
0
0
0
8
0
0
0
% D
% Glu:
8
0
0
0
8
8
70
0
0
0
0
0
0
0
8
% E
% Phe:
0
8
0
0
0
0
8
8
0
0
0
0
93
0
0
% F
% Gly:
0
8
0
0
0
0
0
0
0
0
8
0
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
85
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
93
8
0
0
0
77
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
77
0
0
0
0
0
0
8
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
8
0
0
0
0
0
0
8
0
0
0
0
0
0
8
% N
% Pro:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
8
8
8
0
8
0
0
0
0
8
0
0
0
0
% Q
% Arg:
0
0
0
85
0
0
0
0
0
0
85
0
0
0
0
% R
% Ser:
0
8
0
0
0
0
8
0
0
0
0
0
0
0
0
% S
% Thr:
0
16
0
0
8
0
0
0
0
77
0
0
0
0
0
% T
% Val:
8
0
8
0
8
0
0
0
0
0
0
0
8
8
0
% V
% Trp:
0
0
85
0
0
0
0
8
0
8
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
85
0
77
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _