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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: H6PD All Species: 23.94
Human Site: Y673 Identified Species: 43.89
UniProt: O95479 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95479 NP_004276.2 791 88893 Y673 E D Q G A Q I Y A R E I S A L
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001099298 791 88822 Y673 E D Q G A Q I Y A R E I S A L
Dog Lupus familis XP_546762 789 89091 Y671 E D Q G A Q M Y A S E I S A L
Cat Felis silvestris
Mouse Mus musculus Q8CFX1 789 88892 Y671 E D Q G A Q T Y A S E I S A L
Rat Rattus norvegicus P05370 515 59357 T406 A V Y T K M M T K K P G M F F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513087 312 34898 Y203 E M Y R V D H Y L G K Q A V A
Chicken Gallus gallus XP_425746 782 88274 Y664 E D G G P E L Y A K E I M A L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_697820 781 88168 Y663 E D G G A T L Y E K E I Q K H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P12646 524 60412 G415 K M M T K S P G I T F D I E E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q27464 522 60197 M413 E A V Y M K L M T K K P G M G
Sea Urchin Strong. purpuratus XP_795087 853 96259 Y733 K D G G P E L Y S A E I K R L
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001150684 507 57610 V398 A M Y M K L T V K K P G L E M
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P11412 505 57503 A396 K T P G L S N A T Q V T D L N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 97.4 84.8 N.A. 83.4 23.1 N.A. 30.5 69.2 N.A. 53 N.A. 22.1 N.A. 22.8 39.9
Protein Similarity: 100 N.A. 98.4 91.6 N.A. 90.3 38.4 N.A. 35.4 82.3 N.A. 71.8 N.A. 37.9 N.A. 39.3 55.9
P-Site Identity: 100 N.A. 100 86.6 N.A. 86.6 0 N.A. 13.3 60 N.A. 46.6 N.A. 0 N.A. 6.6 40
P-Site Similarity: 100 N.A. 100 93.3 N.A. 86.6 13.3 N.A. 26.6 80 N.A. 60 N.A. 6.6 N.A. 33.3 66.6
Percent
Protein Identity: N.A. 25.2 N.A. N.A. 22.6 N.A.
Protein Similarity: N.A. 39.7 N.A. N.A. 36.7 N.A.
P-Site Identity: N.A. 0 N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. 13.3 N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 8 0 0 39 0 0 8 39 8 0 0 8 39 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 54 0 0 0 8 0 0 0 0 0 8 8 0 0 % D
% Glu: 62 0 0 0 0 16 0 0 8 0 54 0 0 16 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 8 0 0 8 8 % F
% Gly: 0 0 24 62 0 0 0 8 0 8 0 16 8 0 8 % G
% His: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 8 % H
% Ile: 0 0 0 0 0 0 16 0 8 0 0 54 8 0 0 % I
% Lys: 24 0 0 0 24 8 0 0 16 39 16 0 8 8 0 % K
% Leu: 0 0 0 0 8 8 31 0 8 0 0 0 8 8 47 % L
% Met: 0 24 8 8 8 8 16 8 0 0 0 0 16 8 8 % M
% Asn: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 8 % N
% Pro: 0 0 8 0 16 0 8 0 0 0 16 8 0 0 0 % P
% Gln: 0 0 31 0 0 31 0 0 0 8 0 8 8 0 0 % Q
% Arg: 0 0 0 8 0 0 0 0 0 16 0 0 0 8 0 % R
% Ser: 0 0 0 0 0 16 0 0 8 16 0 0 31 0 0 % S
% Thr: 0 8 0 16 0 8 16 8 16 8 0 8 0 0 0 % T
% Val: 0 8 8 0 8 0 0 8 0 0 8 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 24 8 0 0 0 62 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _